Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications
Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications
复制标题
表没食子儿茶素没食子酸酯基磁性金纳米壳纳米平台用于癌症治疗诊断应用
DOI：
10.1039/c6tb02408d
复制
发表时间：
2017-01-21
影响因子：
7
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Yin, Yanyan;Cui, Lingling;Wang, Lei
近年来，金纳米材料和氧化铁纳米粒子（NPs）因其独特的物理、化学和生物学特性而备受关注。在本研究中，首先制备了聚乙烯亚胺（PEI）修饰的Fe₃O₄纳米粒子（内核），然后以表没食子儿茶素没食子酸酯（EGCG）为还原剂，创新性地在核上形成金壳（AuNSs），从而获得Fe₃O₄ - PEI@AuNSs - EGCG核壳纳米粒子。经过聚乙二醇（PEG）修饰后，Fe₃O₄ - PEI@AuNSs - EGCG/PEG纳米平台构建完成。这种高度集成的纳米平台显示出显著的生物稳定性、快速的细胞摄取能力以及优异的体外和体内抗肿瘤活性。此外，该纳米平台还可用作磁共振（MR）/X射线双模成像造影剂。总之，本研究结果表明，Fe₃O₄ - PEI@AuNSs - EGCG/PEG是一种有前景、潜在有效的肿瘤治疗诊疗一体化纳米平台。
Recently, gold nanomaterials and iron oxide nanoparticles (NPs) have attracted much attention due to their unique physical, chemical and biological properties. In this study, polyethyleneimine (PEI)-modified Fe3O4 NPs (inner cores) were first prepared, and then gold shells (AuNSs) were innovatively formed on the cores using epigallocatechin gallate (EGCG) as the reducing agent to obtain Fe3O4-PEI@AuNSs-EGCG core-shell NPs. After PEG modification, the Fe3O4-PEI@AuNSs-EGCG/PEG nanoplatform was completed. This highly integrated nanoplatform has shown remarkable biostability, rapid cellular uptake, and excellent in vitro and in vivo anti-tumour activity. Moreover, this nanoplatform can also be used as a magnetic resonance (MR)/X-ray dual-mode imaging agent. In all, the results of this study showed that Fe3O4-PEI@AuNSs-EGCG/PEG is a promising, potentially effective, theranostic nanoplatform for tumour treatment.