Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat
Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat
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DOI：
10.1016/j.neulet.2004.12.055
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发表时间：
2005-05-13
影响因子：
2.5
通讯作者：
Brown, VJ
中科院分区：
文献类型：
--
作者：
Groves, DA;Bowman, EM;Brown, VJ
迷走神经刺激（VNS）被用来治疗癫痫，目前正在研究作为抑郁症的治疗方法李晓明，李晓明，李晓明，李晓明，陈晓明，陈晓明，陈晓明，陈晓明。基于脑回路的情绪障碍治疗方法（电刺激、脑电刺激、脑电刺激、脑电刺激）。中国。神经精神病学7 (2002)293-304；刘志强，刘志强，刘志强。迷走神经刺激在神经精神疾病治疗中的应用。[j] .中华精神医学杂志，2003(6):73-83]。VNS的作用机制尚不完全清楚[E]。Ben-Menachem，迷走神经刺激治疗癫痫，Lancet Neurol. 1(2002) 477-482]尽管有许多影像学研究(见E. Ben-Menachem，迷走神经刺激治疗癫痫，Lancet Neurol. 1 (2002) 477-482；李晓明，李晓明，李晓明，李晓明，李晓明，李晓明，李晓明。基于脑回路的情绪障碍治疗方法（电刺激、脑电刺激、脑电刺激、脑电刺激）。中国。神经精神病学7 (2002)293-304；陈晓明，陈晓明，陈晓明。迷走神经刺激（VNS）在神经精神疾病治疗中的应用，中华神经医学杂志，2003,33 (3):393 - 393；M.S. George， H.A. Sackeim， L.B. Marangell， M.M. Husain， Z. Nahas， S.H. Lisanby， J.C. Ballenger， A.J. Rush，迷走神经刺激。难治性抑郁症的潜在疗法？Psychiatr。中国。North Am. 23(2000) 757-783]供参考。然而，有证据表明蓝斑可能在VNS的作用中起调节作用。本研究研究了0.3 mA的VNS（足够强度的VNS）对迷走神经A和B纤维成分的影响伍德伯里,JW。Woodbury，迷走神经刺激对实验性诱导大鼠癫痫发作的影响，epilepsy 31（增刊2）（1990）s7 - s19]，蓝斑单个神经元放电率。这项研究首次证实了在麻醉大鼠的VNS急性刺激后，蓝斑的直接神经元反应。本研究结果表明，蓝斑的神经元活动受到VNS的调节。这种通过蓝斑的通路可能在VNS的临床效果中起重要作用。2005爱思唯尔爱尔兰有限公司版权所有。
Vagal nerve stimulation (VNS) is used as a treatment for Epilepsy and is currently under investigation as a treatment for depression (see [M.S. George, Z. Nahas, X. Li, F.A. Kozel, B. Anderson, K. Yamanaka, J.H. Chae, M.J. Foust, Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS), Semin. Clin. Neuropsychiatry 7 (2002) 293-304; M.S. George, A.J. Rush, H.A. Sackeim, L.B. Marangell, Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders, Int. J. Neuropsychopharmacol. 6 (2003) 73-83] for reviews). The mechanism of action of VNS is not fully understood [E. Ben-Menachem, Vagus-nerve stimulation for the treatment of epilepsy, Lancet Neurol. 1 (2002) 477-482] despite numerous imaging investigations (see (E. Ben-Menachem, Vagus-nerve stimulation for the treatment of epilepsy, Lancet Neurol. 1 (2002) 477-482; M.S. George, Z. Nahas, X. Li, F.A. Kozel, B. Anderson, K. Yamanaka, J.H. Chae, M.J. Foust, Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS), Semin. Clin. Neuropsychiatry 7 (2002) 293-304; M.S. George, A.J. Rush, H.A. Sackeim, L.B. Marangell, Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders, Int J Neuropsychopharmacol 6 (2003) 73-83; M.S. George, H.A. Sackeim, L.B. Marangell, M.M. Husain, Z. Nahas, S.H. Lisanby, J.C. Ballenger, A.J. Rush, Vagus nerve stimulation. A potential therapy for resistant depression? Psychiatr. Clin. North Am. 23 (2000) 757-783] for reviews). However, there is some evidence to suggest that the locus coeruleus may play a role modulating the effects of VNS. This study investigated the effects of VNS (0.3 mA), of sufficient intensity to recruit the A and B fibre components of the vagus [D.M. Woodbury, JW. Woodbury, Effects of vagal stimulation on experimentally induced seizures in rats, Epilepsia 31 (Suppl. 2) (1990) S7-S 19], on the discharge rate of single neurons from the locus coeruleus. This study is the first to demonstrate a direct neuronal response from the locus coeruleus following acute challenge of VNS in the anaesthetised rat. The results of this study indicate that neuronal activity of the locus coeruleus is modulated by VNS. This pathway through the locus coeruleus may be significant for mediating the clinical effects of VNS. (c) 2005 Elsevier Ireland Ltd. All rights reserved.