Brain angiotensin receptors and binding proteins.
Brain angiotensin receptors and binding proteins.
复制标题
脑血管紧张素受体和结合蛋白。
DOI：
10.1007/s00210-007-0238-7
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Karamyan,VardanT
中科院分区：
文献类型：
--
作者：
Speth,RobertC;Karamyan,VardanT
This review addresses classical and novel aspects of the brain angiotensin system. The brain contains both the AT1and AT2angiotensin II (Ang II) receptor subtypes which are well-characterized guanine nucleotide binding protein (G protein)-coupled receptors (GPCRs). Like other GPCRs, novel signal transduction pathways and protein interactions are being described for Ang II receptors. For brain AT1receptors, there is a controversy regarding the identity of the active angiotensin peptide in the brain which is addressed in this review. This review also summarizes a recent discovery of a novel, membrane-bound, non-AT1, non-AT2binding site for angiotensin peptides that appears to be brain-specific. This binding site is unmasked by a limited concentration range of the organometallic sulfhydryl-reactive agent p-chloromercuribenzoic acid (PCMB) suggesting that functional expression of this binding site may depend on the redox state of the milieu of the brain. While this binding site has similarities to a previously described soluble angiotensin-binding protein found in liver that is unmasked by PCMB, it has many different characteristics. The possible functional significance of this novel non-AT1, non-AT2binding site for angiotensin peptides as a mediator of non-traditional actions of Ang II in the brain, e.g., stimulation of dopamine release from the striatum, as a peptidase, or as a clearance receptor, and the importance of the state of the internal environment of the brain to its function is reviewed.
