Extensive impact of non-antibiotic drugs on human gut bacteria.
Extensive impact of non-antibiotic drugs on human gut bacteria.
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DOI：
10.1038/nature25979
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发表时间：
2018-03-29
期刊：
影响因子：
64.8
通讯作者：
Typas A
中科院分区：
文献类型：
--
作者：
Maier L;Pruteanu M;Kuhn M;Zeller G;Telzerow A;Anderson EE;Brochado AR;Fernandez KC;Dose H;Mori H;Patil KR;Bork P;Typas A
一些常用的非抗生素药物最近与肠道微生物组组成的变化有关，但这种现象的程度尚不清楚。我们对40种具有代表性的肠道细菌菌株筛选了1000种上市药物，发现24%的人类靶点药物（包括所有治疗类别的成员）至少抑制了一种菌株的生长。某些特定类别，如化学成分多样的抗精神病药物，被过度代表。人类靶向药物对肠道细菌的影响反映在其对人类的抗生素样副作用上，并且与现有的人类队列研究一致，为我们的筛选提供了体内相关性。对抗生素和人类靶向药物的敏感性在不同细菌种类之间存在相关性，这表明非抗生素可能促进抗生素耐药性。我们的研究结果为未来药物-微生物相互作用的研究提供了全面的资源，为副作用控制和药物再利用开辟了新的途径，并拓宽了我们对抗生素耐药性的看法。
A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. We screened >1000 marketed drugs against 40 representative gut bacterial strains, and found that 24% of the drugs with human targets, including members of all therapeutic classes, inhibited the growth of at least one strain. Particular classes such as the chemically diverse antipsychotics were overrepresented. The effects of human-targeted drugs on gut bacteria are reflected on their antibiotic-like side effects in humans and are concordant with existing human cohort studies, providing in vivo relevance for our screen. Susceptibility to antibiotics and human-targeted drugs correlates across bacterial species, suggesting that non-antibiotics may promote antibiotic resistance. Our results provide a comprehensive resource for future research on drug-microbiome interactions, opening new paths for side effect control and drug repurposing, and broaden our view on antibiotic resistance.