Prophylactic laparoscopic total gastrectomy for gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): the first report in Asia
Prophylactic laparoscopic total gastrectomy for gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): the first report in Asia
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DOI：
10.1007/s10120-021-01253-x
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发表时间：
2021-09-23
期刊：
影响因子：
7.4
通讯作者：
Baba, Hideo
中科院分区：
文献类型：
--
作者：
Matsumoto, Chihiro;Iwatsuki, Masaaki;Baba, Hideo
一位41岁的女性因胃脘痛入院。她因胃底腺息肉病（FGP）而被另一家医院收治，没有任何症状，在她之前的内窥镜检查中没有发现恶性肿瘤。然而，在我们医院进行的活检显示腺癌，计算机断层扫描（CT）显示多个肝脏和腹膜转移。我们临床上怀疑胃腺癌和胃近端息肉病（GAPPS），并表示基因检测。APC基因外显子1B存在点突变。她被诊断为GAPPS伴多发性肝转移，并接受了全身化疗。她有两个哥哥也患有FGP。在两个兄弟和他们的母亲身上都观察到了相同的基因组突变，他们也被诊断出患有GAPPS。两兄弟接受了预防性腹腔镜全胃切除术和D1淋巴结清扫术。
A 41-year-old woman was admitted to our hospital for epigastralgia. She had been admitted to another hospital for fundic gland polyposis (FGP) without any symptoms, and no malignancy had been noted in her previous endoscopy. However, a biopsy performed at our hospital revealed adenocarcinoma, and computed tomography (CT) revealed multiple liver and peritoneal metastases. We clinically suspected gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) and indicated genetic testing. The point mutation in exon 1B of APC was revealed. She was diagnosed with GAPPS with multiple liver metastases and underwent systemic chemotherapy. She has two older brothers who also have FGP. The same genomic mutation was observed in both brothers and their mother, and they were also diagnosed with GAPPS. The brothers underwent prophylactic laparoscopic total gastrectomy with D1 lymph-node dissection.