Extreme morning chronotypes are often familial and not exceedingly rare: the estimated prevalence of advanced sleep phase, familial advanced sleep phase, and advanced sleep-wake phase disorder in a sleep clinic population
Extreme morning chronotypes are often familial and not exceedingly rare: the estimated prevalence of advanced sleep phase, familial advanced sleep phase, and advanced sleep-wake phase disorder in a sleep clinic population
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DOI：
10.1093/sleep/zsz148
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发表时间：
2019-10-01
期刊：
影响因子：
5.6
通讯作者：
Jones, Christopher R.
中科院分区：
文献类型：
--
作者：
Curtis, Brian John;Ashbrook, Liza H.;Jones, Christopher R.
研究目的：报告第一次估计的患病率提前睡眠阶段（ASP），家族性提前睡眠阶段（fASP），和先进的睡眠-觉醒阶段障碍（ASWPD）。这可以指导临床医生的实用程序的筛选极端的时钟类型的临床决策和标记的前瞻性参与者的遗传学和生物学的FASP.Methods的研究：早晨或晚上的睡眠时间表偏好（时钟类型）的数据收集了2422新的患者提出了北美睡眠中心超过9.8年。FASP是使用一个严重性标准来确定的，该标准以前已经确定了人类的显性昼夜节律突变。所有患者均由其中一位作者（C. R. J.）亲自观察和评估。结果：我们的研究结果表明ASP患病率为0.33%，FASP患病率为0.21%，ASWPD患病率至少为0.04%。大多数情况下，起病的ASP是family.Conclusions：在患者提出的睡眠诊所，保守的1每300例患者将有ASP，1每475将有FASP，和1每2500将有ASWPD。这支持获得常规的昼夜节律史，对于那些具有极端时钟类型的人，获得昼夜节律偏好的家族史。这可以优化晚上嗜睡和清晨醒来的治疗，并导致额外的昼夜节律基因的发现。我们希望这些发现将在未来为广泛的睡眠和医学障碍提供更好的治疗选择。
Study Objectives: Report the first prevalence estimates of advanced sleep phase (ASP), familial advanced sleep phase (FASP), and advanced sleep-wake phase disorder (ASWPD). This can guide clinicians on the utility of screening for extreme chronotypes both for clinical decision-making and to flag prospective participants in the study of the genetics and biology of FASP.Methods: Data on morning or evening sleep schedule preference (chronotype) were collected from 2422 new patients presenting to a North American sleep center over 9.8 years. FASP was determined using a severity criterion that has previously identified dominant circadian mutations in humans. All patients were personally seen and evaluated by one of the authors (C.R.J.).Results: Our results demonstrate an ASP prevalence of 0.33%, an FASP prevalence of 0.21%, and an ASWPD prevalence of at least 0.04%. Most cases of young-onset ASP were familial.Conclusions: Among patients presenting to a sleep clinic, conservatively 1 out of every 300 patients will have ASP, 1 out of every 475 will have FASP, and 1 out of every 2500 will have ASWPD. This supports obtaining a routine circadian history and, for those with extreme chronotypes, obtaining a family history of circadian preference. This can optimize treatment for evening sleepiness and early morning awakening and lead to additional circadian gene discovery. We hope these findings will lead to improved treatment options for a wide range of sleep and medical disorders in the future.