A feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation for malignant pleural mesothelioma.
A feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation for malignant pleural mesothelioma.
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诱导培美曲塞加顺铂联合胸膜外全肺切除术和术后半胸放疗治疗恶性胸膜间皮瘤的可行性研究。
DOI：
10.1093/jjco/hyn145
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发表时间：
2008
影响因子：
2.4
通讯作者：
T. Nakano
中科院分区：
文献类型：
--
作者：
T. Yamanaka;F. Tanaka;S. Hasegawa;M. Okada;T. Soejima;N. Kamikonya;K. Fukuoka;T. Nakano
在日本开始了一项前瞻性多机构研究，以评价可切除的恶性胸膜间皮瘤患者接受培美曲塞+顺铂诱导化疗，随后进行胸膜外全肺切除术（EPP）和术后半胸放疗的可行性。该研究于2008年5月启动，将在3年内招募40例患者。主要终点是EPP的肉眼完全切除率和三联疗法的治疗相关死亡率。次要终点包括治疗完成率、不良事件、化疗反应率和2年总生存率和无复发生存率。
A prospective multi-institutional study has been commenced in Japan to evaluate the feasibility of induction chemotherapy using pemetrexed plus cisplatin, followed by extrapleural pneumonectomy (EPP) and postoperative hemithoracic radiation in patients with resectable malignant pleural mesothelioma. The study was initiated on May 2008 and 40 patients will be recruited over 3 years. Primary endpoints are macroscopic complete resection rate by EPP and treatment-related mortality for trimodality therapy. Secondary endpoints include treatment completion rate, adverse events, response rate by chemotherapy and 2-year overall and relapse-free survival.