Embedding a Linkage to Preexposure Prophylaxis Care Intervention in Social Network Strategy and Partner Notification Services: Results From a Pilot Randomized Controlled Trial.
Embedding a Linkage to Preexposure Prophylaxis Care Intervention in Social Network Strategy and Partner Notification Services: Results From a Pilot Randomized Controlled Trial.
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DOI：
10.1097/qai.0000000000002548
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发表时间：
2021-02-01
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影响因子：
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通讯作者：
Schneider JA
中科院分区：
文献类型：
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作者：
Teixeira da Silva D;Bouris A;Ramachandran A;Blocker O;Davis B;Harris J;Pyra M;Rusie LK;Brewer R;Pagkas-Bather J;Hotton A;Ridgway JP;McNulty M;Bhatia R;Schneider JA
需要增加与男性发生性关系的黑人男性和黑人变性女性（BMSM/TW）的暴露前预防（PrEP）摄入量，以结束艾滋病毒流行病。在网络服务中嵌入简短的干预措施，使个人参与艾滋病毒传播网络进行艾滋病毒/性传播感染检测，可能是加速PrEP吸收的重要战略。合作伙伴服务PrEP（PS-PrEP）研究是一项试点随机对照试验，旨在改善2015年至2017年在伊利诺伊州芝加哥接受网络服务的BMSM/TW与PrEP护理的联系。BMSM/TW（N=146），年龄18-40岁，从网络服务（合作伙伴服务和社会网络战略服务）招募。干预的参与者制定了一个个性化的连接计划的基础上的信息动机行为技能模型，并收到了迷你助推器会议。对照组受试者照常接受治疗。在基线、干预后3个月和12个月检查社会人口统计学、行为和临床因素。意向治疗分析在干预后三个月内检查与PrEP护理的联系（主要结局）。次要结局是PrEP启动，与PrEP护理联系的时间以及PrEP启动的时间。与对照参与者相比，干预参与者中有更大比例的人在三个月内与PrEP护理（24%对11%; p=0.04）和启动PrEP（24%对11%，p=0.05）有关。在研究期间与PrEP护理相关的人群中，干预参与者的联系明显早于对照参与者（中位数[四分位距]天，26.5 [6.0，141.8] vs. 191.5 [21.5，297.0]; p=0.05）。研究结果支持PS-PrEP在改善BMSM/TW与PrEP护理和PrEP启动之间的联系方面的初步疗效。
Increased pre-exposure prophylaxis (PrEP) uptake among Black men who have sex with men and Black transgender women (BMSM/TW) is needed to end the HIV epidemic. Embedding a brief intervention in network services that engage individuals in HIV transmission networks for HIV/STI testing may be an important strategy to accelerate PrEP uptake. Partner Services PrEP (PS-PrEP) study is a pilot randomized control trial to improve linkage to PrEP care among BMSM/TW presenting for network services in Chicago, IL from 2015 to 2017. BMSM/TW (N=146) aged 18–40 were recruited from network services (partners services and social network strategy services). Intervention participants developed an individualized linkage plan based on the Information-Motivation-Behavioral Skills model and received mini-booster sessions. Control participants received treatment as usual. Socio-demographic, behavioral, and clinical factors were examined at baseline, three- and 12-months post-intervention. Intent-to-treat analyses examined linkage to PrEP care within three months post-intervention (primary outcome). Secondary outcomes were PrEP initiation, time to linkage to PrEP care, and time to PrEP initiation. Compared to control participants, a significantly greater proportion of the intervention participants were linked to PrEP care within three months (24% vs. 11%; p=0.04) and initiated PrEP (24% vs. 11%, p=0.05). Among those linked to PrEP care within the study period, intervention participants were linked significantly sooner than control participants (median [interquartile range] days, 26.5 [6.0, 141.8] vs. 191.5 [21.5, 297.0]; p=0.05). Study results support the preliminary efficacy of PS-PrEP to improve linkage to PrEP care and PrEP initiation among BMSM/TW.