Leveraging epigenetics to enhance the efficacy of immunotherapy.
Leveraging epigenetics to enhance the efficacy of immunotherapy.
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DOI：
10.1186/s13148-021-01100-x
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发表时间：
2021-05-17
影响因子：
5.7
通讯作者：
Bennett RL
中科院分区：
文献类型：
--
作者：
Licht JD;Bennett RL
表观遗传机制调控染色质可及性模式，该模式支配转录机制与基因及其顺式调控元件的相互作用。影响表观遗传机制的突变在癌症中很常见。由于表观遗传修饰是可逆的，许多针对这些机制的抗癌策略目前正在开发和临床试验中。在这里，我们回顾了表明表观遗传疗法可以抑制免疫抑制基因的表达或重新编程肿瘤细胞以激活抗原递送机制的证据。此外，癌症中常见的表观遗传机制的失调可能会改变肿瘤细胞的免疫原性和免疫治疗的有效性。针对表观遗传机制的治疗可能有助于对抗免疫逃避，提高免疫治疗的有效性。
Epigenetic mechanisms regulate chromatin accessibility patterns that govern interaction of transcription machinery with genes and their cis-regulatory elements. Mutations that affect epigenetic mechanisms are common in cancer. Because epigenetic modifications are reversible many anticancer strategies targeting these mechanisms are currently under development and in clinical trials. Here we review evidence suggesting that epigenetic therapeutics can deactivate immunosuppressive gene expression or reprogram tumor cells to activate antigen presentation mechanisms. In addition, the dysregulation of epigenetic mechanisms commonly observed in cancer may alter the immunogenicity of tumor cells and effectiveness of immunotherapies. Therapeutics targeting epigenetic mechanisms may be helpful to counter immune evasion and improve the effectiveness of immunotherapies.
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影响因子：
5.2
作者：
Di Martino MT;Riillo C;Scionti F;Grillone K;Polerà N;Caracciolo D;Arbitrio M;Tagliaferri P;Tassone P
通讯作者：
Tassone P
影响因子：
10.3
作者：
Cortez, Maria Angelica;Ivan, Cristina;Welsh, James W.
通讯作者：
Welsh, James W.
从头表观遗传程序抑制PD-1封锁介导的T细胞再生。
影响因子：
64.5
作者：
Ghoneim HE;Fan Y;Moustaki A;Abdelsamed HA;Dash P;Dogra P;Carter R;Awad W;Neale G;Thomas PG;Youngblood B
通讯作者：
Youngblood B
影响因子：
9
作者：
Colangelo T;Polcaro G;Ziccardi P;Pucci B;Muccillo L;Galgani M;Fucci A;Milone MR;Budillon A;Santopaolo M;Votino C;Pancione M;Piepoli A;Mazzoccoli G;Binaschi M;Bigioni M;Maggi CA;Fassan M;Laudanna C;Matarese G;Sabatino L;Colantuoni V
通讯作者：
Colantuoni V
影响因子：
8.8
作者：
Chatterjee, Annesha;Jana, Samir;Bhattacharyya, Arindam
通讯作者：
Bhattacharyya, Arindam