In vitro application of Fe/MgO nanoparticles as magnetically mediated hyperthermia agents for cancer treatment
In vitro application of Fe/MgO nanoparticles as magnetically mediated hyperthermia agents for cancer treatment
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DOI：
10.1016/j.jmmm.2010.10.043
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发表时间：
2011-03-01
影响因子：
2.7
通讯作者：
Kalogirou, O.
中科院分区：
文献类型：
--
作者：
Chalkidou, A.;Simeonidis, K.;Kalogirou, O.
本文研究了Fe/MgO磁芯/生物相容性壳纳米颗粒的加热效率及其在体外对癌细胞进行磁热疗的应用。不同的人乳腺癌细胞系被用来评估纳米颗粒在体内应用的适用性。实验表明，该材料具有良好的细胞毒性和显著的吸收效率，以及相对较高的比吸收率和快速的热响应，这些特征对于获得足够的热效率和最短的治疗时间至关重要。(C) 2010 Elsevier B.V.版权所有
In this work we study the heating efficiency of Fe/MgO magnetic core/biocompatible shell nanoparticles and their in vitro application in magnetic hyperthermia on cancer cells. Different human breast cancer cell lines were used to assess the suitability of nanoparticles for in vivo application. The experiments revealed a very good cytotoxicity profile and significant uptake efficiency together with relatively high specific absorption rates and fast thermal response, features that are crucial for adequate thermal efficiency and minimum duration of treatment. (C) 2010 Elsevier B.V. All rights reserved.