The effects of isoflurane and halothane on blood flow and 31P NMR spectra in murine RIF-1 tumors.
The effects of isoflurane and halothane on blood flow and 31P NMR spectra in murine RIF-1 tumors.
复制标题
异氟烷和氟烷对鼠 RIF-1 肿瘤血流和 31P NMR 谱的影响。
DOI：
10.1002/mrm.1910330505
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发表时间：
1995
影响因子：
3.3
通讯作者：
Evelhoch,JL
中科院分区：
文献类型：
--
作者：
Zhao,M;Fortan,LG;Evelhoch,JL
这些研究的主要目的是评估异氟烷和氟烷在肿瘤生理学NMR研究中的效用。在体内，31 P和2 H NMR用于检查麻醉前、麻醉期间和麻醉后（对于31 P）的RIF-1肿瘤。在肿瘤中，氟烷可降低血流量、[PCR]：[NTP]和pH值（由P1化学位移（pHnmr）表示），同时增加[P1：[NTP];其作用与氟烷已确立的心血管作用一致。异氟醚不影响肿瘤血流量或[PCr]：[NTP]，但增加肿瘤[P1]：[NTP]并降低肿瘤pHnmr。正常小鼠肝脏（上腹部）的体内31 P NMR测量表明异氟醚在肝脏中具有类似的作用。尽管这些效应的机制尚不清楚，但在异氟烷麻醉期间观察到的分裂P1峰表明，在异氟烷麻醉下，较低pH环境中的P1池可能变得明显。无论[P1：[NTP]升高和pHnmr降低的原因是什么，异氟烷麻醉用于能量代谢的31 P NMR研究的效用是有限的。
The principal aim of these studies was to evaluate the utility of isoflurane and halothane for NMR investigations of tumor physiology.In vivo31P and2H NMR were used to examine RIF‐1 tumors before, during, and (for31P) after anesthesia. In tumors, halothane decreases blood flow, [PCR]:[NTP], and pH indicated by theP1chemical shift (pHnmr), while it increases [P1:[NTP]; effects consistent with well‐established cardiovascular effects of halothane. Isoflurane does not affect tumor blood flow or [PCr]:[NTP], but increases tumor [P1:[NTP] and decreases tumor pHnmr.In vivo31P NMR measurements of normal mouse liver (upper abdomen) indicate that isoflurane has a similar effect in the liver. Although the mechanism for these effects is unknown, observation of a splitP1peak during isoflurane anesthesia suggests that a pool ofP1in a lower pH environment may become evident under isoflurane anesthesia. Regardless of the cause for increased [P1:[NTP] and decreased pHnmrthe utility of isoflurane anesthesia for31P NMR studies of energy metabolism is limited.