Distinctive features of adult ocular dominance plasticity.
Distinctive features of adult ocular dominance plasticity.
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DOI：
10.1523/jneurosci.2451-08.2008
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发表时间：
2008-10-08
期刊：
影响因子：
--
通讯作者：
Stryker MP
中科院分区：
文献类型：
--
作者：
Sato M;Stryker MP
感官体验深刻地塑造了青少年大脑的神经回路。尽管成年啮齿动物的视皮层在单眼视觉剥夺后仍具有可塑性，但这种可塑性的本质及其伴随的神经回路变化仍然是个谜。在这里，我们使用傅立叶光学成像对小鼠视皮层的内在信号进行成像，研究成人和青少年眼优势可塑性之间的差异。这一比较表明，成年小鼠的可塑性比幼年小鼠需要更长的时间，幅度较小，对睁开眼睛的反应增加的贡献更大，对剥夺眼睛的同侧大脑半球的影响较小。双眼剥夺也会导致成年人出现不同的变化。成体可塑性类似于幼体可塑性，其依赖于通过NMDA受体传递的信号。我们认为，成人的眼优势可塑性来自于补偿机制，以抵消视觉剥夺导致的传入活动的丧失。
Sensory experience profoundly shapes neural circuitry of juvenile brain. Although the visual cortex of adult rodents retains a capacity for plasticity in response to monocular visual deprivation, the nature of this plasticity and the neural circuit changes that accompany it remain enigmatic. Here we investigate differences between adult and juvenile ocular dominance plasticity using Fourier optical imaging of intrinsic signals in mouse visual cortex. This comparison reveals that adult plasticity takes longer than in the juvenile mouse, is of smaller magnitude, has a greater contribution from the increase in response to the open eye, and has less effect on the hemisphere ipsilateral to the deprived eye. Binocular deprivation also causes different changes in the adult. Adult plasticity is similar to juvenile plasticity in its dependence on signaling through NMDA receptors. We propose that adult ocular dominance plasticity arises from compensatory mechanisms that counterbalance the loss of afferent activity caused by visual deprivation.