Actions of certain amines on cerebral cortical neurones.
Actions of certain amines on cerebral cortical neurones.
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某些胺对大脑皮质神经元的作用。
DOI：
10.1111/j.1476-5381.1963.tb01484.x
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发表时间：
1963
期刊：
影响因子：
--
通讯作者：
J. Phillis
中科院分区：
文献类型：
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作者：
K. Krnjević;J. Phillis
通过微量移液管释放离子电渗疗法，对猫大脑皮层神经元测试了多种色胺和苯乙胺衍生物以及某些其他化合物。许多这些化合物的特征作用是抑制由突触活动或使用 L-谷氨酸引发的神经元放电。咪唑乙酸、多巴胺、麻黄碱和麦角新碱特别有效。儿茶酚胺、羟色胺和咪唑乙酸具有相对较快且快速可逆的作用，与γ-氨基丁酸的作用不同，而麻黄碱和麦角酸二乙酰胺衍生物会导致较慢且较长时间的尖峰振幅抑制，与阿托品相当。当使用较大剂量时，包括 5-羟色胺、肾上腺素和麦角新碱在内的几种化合物也可以兴奋相同的神经元。一些物质，例如多巴和甲基麦角新碱，具有主要的兴奋作用。
A number of derivatives of tryptamine and phenethylamine, and certain other compounds, were tested on neurones in the cerebral cortex of cats by iontophoretic release from micro-pipettes. The characteristic action of many of these compounds was a depression of the neuronal discharge initiated by synaptic activity or by the application of L-glutamate; imidazolylacetic acid, dopamine, ephedrine and ergometrine were particularly effective. Catechol amines, hydroxytryptamines and imidazolylacetic acid had a relatively quick and rapidly reversible action, not unlike that of gamma-aminobutyric acid, whereas ephedrine and derivatives of lysergic acid diethylamide caused a slower and more prolonged depression of the amplitude of spikes, rather like atropine. Several compounds, including 5-hydroxytryptamine, adrenaline and ergometrine, could also excite the same neurone when larger amounts were applied. A few substances, such as dopa and methylergometrine, had a predominantly excitant action.