SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective.
SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective.
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DOI：
10.1007/978-1-4939-0817-2_3
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发表时间：
2014
影响因子：
--
通讯作者：
Kinsey, William H.
中科院分区：
文献类型：
--
作者：
Kinsey, William H.
卵母细胞是一种高度特化的细胞，准备以识别和整合单个精子、完成减数分裂、重新编程母本和父本基因组并将其组装成独特的合子基因组以及最终启动有丝分裂细胞周期所需的一组独特的动作来响应受精。卵母细胞通过一系列信号转导途径组分完成这一系列不同的事件，这些组分包括蛋白酪氨酸激酶的特征性集合。src家族蛋白激酶在该信号阵列中起重要作用，并且卵母细胞特征性地以高水平表达某些SFK以提供卵母细胞必须执行的独特动作。SFK通常在卵母细胞中表现出独特的亚细胞定位模式，并在卵母细胞成熟和受精过程中的不同步骤在不同的亚细胞区室中执行关键功能。虽然SFK信号传导的许多方面在来自不同物种的卵母细胞中是保守的，但是在来自外部受精的物种与内部受精的物种的卵母细胞使用src家族介导的途径的程度上存在显著差异。几个需要SFK信号的卵母细胞功能似乎代表了人类辅助生殖技术中常见的失败点，这一观察结果突出了这些信号通路对人类生殖健康的重要性。
The oocyte is a highly specialized cell poised to respond to fertilization with a unique set of actions needed to recognize and incorporate a single sperm, complete meiosis, reprogram maternal and paternal genomes and assemble them into a unique zygotic genome, and finally initiate the mitotic cell cycle. Oocytes accomplish this diverse series of events through an array of signal transduction pathway components that include a characteristic collection of protein tyrosine kinases. The src-family protein kinases figure importantly in this signaling array and oocytes characteristically express certain SFKs at high levels to provide for the unique actions that the oocyte must perform. The SFKs typically exhibit a distinct pattern of subcellular localization in oocytes and perform critical functions in different subcellular compartments at different steps during oocyte maturation and fertilization. While many aspects of SFK signaling are conserved among oocytes from different species, significant differences exist in the extent to which src-family -mediated pathways are used by oocytes from species that fertilize externally vs those which are fertilized internally. The observation that several oocyte functions which require SFK signaling appear to represent common points of failure during assisted reproductive techniques in humans, highlights the importance of these signaling pathways for human reproductive health.
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