Aging reduces neural specialization in ventral visual cortex
Aging reduces neural specialization in ventral visual cortex
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DOI：
10.1073/pnas.0405148101
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发表时间：
2004-08-31
影响因子：
11.1
通讯作者：
Smith, MR
中科院分区：
文献类型：
--
作者：
Park, DC;Polk, TA;Smith, MR
本研究调查了神经结构是否随着年龄的增长而变得功能分化和专业化。我们研究了腹侧视觉皮层，这是年轻人大脑中对视觉类别（面孔，地点和单词）有选择性反应的区域，并且随着年龄的增长几乎没有萎缩。功能性磁共振成像被用来估计这一皮层区域的神经活动，而年轻人和老年人则观察面孔、房屋、假词和椅子。结果表明，在一系列分析中，老年人对这些刺激类别的神经专业化程度明显降低。
The present study investigated whether neural structures become less functionally differentiated and specialized with age. We studied ventral visual cortex, an area of the brain that responds selectively to visual categories (faces, places, and words) in young adults, and that shows little atrophy with age. Functional MRI was used to estimate neural activity in this cortical area, while young and old adults viewed faces, houses, pseudowords, and chairs. The results demonstrated significantly less neural specialization for these stimulus categories in older adults across a range of analyses.