Area-specific Modulation of Functional Cortical Activity During Block-based and Trial-based Proactive Inhibition
Area-specific Modulation of Functional Cortical Activity During Block-based and Trial-based Proactive Inhibition
复制标题
基于块和基于试验的主动抑制过程中功能性皮层活动的区域特异性调节
DOI：
10.1016/j.neuroscience.2018.07.039
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发表时间：
2018
期刊：
影响因子：
3.3
通讯作者：
Isomura Yoshikazu
中科院分区：
文献类型：
--
作者：
Yoshida Junichi;Saiki Akiko;Soma Shogo;Yamanaka Ko;Nonomura Satoshi;Rios Alain;Kawabata Masanori;Kimura Minoru;Sakai Yutaka;Isomura Yoshikazu
动物可以根据环境背景的变化提前抑制其行为反应（前摄抑制：延迟反应的开始），这是一个多个皮层区域可能参与的过程。然而，目前还不清楚这一过程是如何适应性地调节根据上下文的变化，在不同的时间尺度。为了解决这个问题，我们使用了一个改进的停止信号任务范式的行为和电生理特征的时间方面的前摄抑制在头部固定的大鼠。在这个任务中，他们必须尽可能快地对开始提示做出反应（开始试验），但如果停止提示跟随在开始提示之后（停止试验），他们不必做出反应。该任务在一组只进行试验（G-块）和一组进行和停止试验（GS-块）之间交替进行。我们观察到基于块和基于试验的前摄抑制（出现在GS块和停止试验后，分别）通过行为评估的反应时间延迟在正确的去试验取决于不同的时间尺度上的上下文变化。我们的电生理分析任务相关的神经元活动在初级和次级运动，后顶叶，眶额皮质（M1，M2，PPC，和OFC，分别）。在基于阻断的前摄抑制下，线索偏好OFC神经元的锋电位活动持续减弱，而M1和M2活动在运动准备过程中增强。随后，M1活动在运动决策/执行过程中减弱。在基于试验的前摄抑制下，OFC活性持续增强，PPC和M1活性也在运动决策/执行期间短暂增强。这些结果表明，不同的皮质机制的基础上的两种类型的前摄抑制在啮齿动物。
Animals can suppress their behavioral response in advance according to changes in environmental context (proactive inhibition: delaying the start of response), a process in which several cortical areas may participate. However, it remains unclear how this process is adaptively regulated according to contextual changes on different timescales. To address the issue, we used an improved stop-signal task paradigm to behaviorally and electrophysiologically characterize the temporal aspect of proactive inhibition in head-fixed rats. In the task, they must respond to a go cue as quickly as possible (go trial), but did not have to respond if a stop cue followed the go cue (stop trial). The task alternated between a block of only go trials (G-block) and a block of go-and-stop trials (GS-block). We observed block-based and trial-based proactive inhibition (emerging in GS-block and after stop trial, respectively) by behaviorally evaluating the delay in reaction time in correct go trials depending on contextual changes on different timescales. We electrophysiologically analyzed task-related neuronal activity in the primary and secondary motor, posterior parietal, and orbitofrontal cortices (M1, M2, PPC, and OFC, respectively). Under block-based proactive inhibition, spike activity of cue-preferring OFC neurons was attenuated continuously, while M1 and M2 activity was enhanced during motor preparation. Subsequently, M1 activity was attenuated during motor decision/execution. Under trial-based proactive inhibition, the OFC activity was continuously enhanced, and PPC and M1 activity was also enhanced shortly during motor decision/execution. These results suggest that different cortical mechanisms underlie the two types of proactive inhibition in rodents.