A Low Cost Sensitive Transrectal Photoacoustic Probe With Single-Fiber Bright-Field Illumination for In Vivo Canine Prostate Imaging and Real-Time Biopsy Needle Guidance
A Low Cost Sensitive Transrectal Photoacoustic Probe With Single-Fiber Bright-Field Illumination for In Vivo Canine Prostate Imaging and Real-Time Biopsy Needle Guidance
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DOI：
10.1109/jsen.2020.2993884
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发表时间：
2020-09-15
影响因子：
4.3
通讯作者：
Liu, Chengbo
中科院分区：
文献类型：
--
作者：
Cong, Bing;Qiu, Chen;Liu, Chengbo
在使用光声成像（派）实施前列腺癌筛查中，用于信号检测的经直肠光递送和经直肠超声（TRUS）换能器是派系统设计的最常用方法。在这种方法中，节能的光传输以及激光激发和声学检测的良好对准对于最佳成像灵敏度非常重要。以前发表的作品采用暗场照明的探头。在这项研究中，我们提出并实现了明场照明，这使得更多的激光能量被传递到感兴趣的区域进行成像，从而提高了探头的灵敏度。此外，通过使用单个光纤代替光纤束，激光传输的效率显著提高。单根光纤的采用也提高了探头操作的灵活性，降低了成本。本研究建立了一个定制设计的光声成像系统，以验证探针用于临床平移应用的可行性。利用体模的派对所提出的探头的空间分辨率和增强的信噪比（SNR）进行了验证。我们使用模拟前列腺癌的犬模型证明了探针在体内诊断前列腺癌中的用途。我们的研究结果表明，该探头可以实现高灵敏度和宽视场（FOV）成像前列腺癌。我们还进行了体外前列腺穿刺活检的微创实时引导，显示了探针用于前列腺癌早期筛查和前列腺肿瘤早期预防性治疗的潜力。
In implementing prostate cancer screening using photoacoustic imaging (PAI), transrectal delivery of light and transrectal ultrasound (TRUS) transducer for signal detection is the most commonly used approach for PAI system design. In this approach, energy-efficient light delivery and good alignment of laser excitation and acoustic detection are very important for optimal imaging sensitivity. The previously published works adopted dark-field illumination for their probes. In this study, we proposed and achieved bright-field illumination, which enables more laser energy to be delivered to the region of interest for imaging, resulting in higher sensitivity of the probe. Further, by using a single optical fiber instead of fiber bundle, the efficiency of laser transmission was significantly enhanced. The adoption of single optical fiber also enhances the flexibility of the probe for operation and lower the cost. A custom designed photoacoustic imaging system was built in this study to verify the feasibility of the probe for clinical translational application. The spatial resolution and enhanced signal-to-noise ratio (SNR) of the proposed probe were validated using PAI of phantoms. We demonstrated the use of probe in diagnosing prostate cancer in vivo using a canine model mimicking prostate cancer. Our results showed that the proposed probe could achieve high sensitivity and a wide field-of-view (FOV) in imaging prostate cancer. We also performed minimally-invasive real-time guidance of needle biopsy in ex vivo prostate, showing the potential of the probe for early screening of prostate cancer and early preventive treatment of prostate tumor.