Poor autonomic nervous system functioning during sleep in recently detoxified alcohol-dependent men and women.
Poor autonomic nervous system functioning during sleep in recently detoxified alcohol-dependent men and women.
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DOI：
10.1111/acer.12384
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Colrain IM
中科院分区：
文献类型：
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作者：
de Zambotti M;Baker FC;Sugarbaker DS;Nicholas CL;Trinder J;Colrain IM
酒精中毒被认为是心血管疾病的重要风险因素。自主神经系统(ANS)功能是心血管健康的主要指标。睡眠是研究ANS活动的合适模型，没有与清醒相关的混杂因素。我们调查了慢性酒精中毒患者夜间ANS功能，以及ANS活性与酒精依赖严重程度之间的关系。14名近期戒酒患者(年龄：42.0±9.0岁，7名女性)和16名年龄和性别匹配的对照组(年龄：45.2±9.1岁，8名女性)接受了一夜的标准临床多导睡眠监测，包括心电图记录。心率变异性(HRV)的时间和频域频谱分析在夜间和无伪影的稳定睡眠和清醒时期(睡前觉醒、快速眼动(REM)和非REM睡眠)进行。与对照组相比，酗酒者的主观和客观睡眠质量较差。在整个晚上，酗酒的男性和女性心率加快，总心率变异性降低，即正常到正常心搏间期的标准差较低，高频活动减少(通过高频功率和连续心动周期差的均方根来评估)。这种ANS模式在夜间开始时最为明显。没有一项ANS测量与终生饮酒或酒精依赖持续时间相关。我们的结果显示，ANS功能在夜间受到干扰，甚至在未受干扰的睡眠期间也是如此，这表明最近戒酒的男性和女性心血管功能较差。
Alcoholism is considered an important risk factor for cardiovascular disease. Autonomic nervous system (ANS) function is a major indicator of cardiovascular health. Sleep is a suitable model to investigate ANS activity free from wake-related confounders. We investigated night-time ANS functioning, and the relationship between ANS activity and severity of alcohol dependence in chronic alcoholism. Fourteen recently abstaining alcoholics (Age: 42.0±9.0y, 7 women) and sixteen age- and sex-matched controls (Age: 45.2±9.1y, 8 women) underwent a night of standard clinical polysomnography, including electrocardiographic recording. Time- and frequency-domain spectral analysis of heart rate variability (HRV) was performed across hours of the night and during artifact-free epochs of stable sleep and wakefulness (pre-sleep wakefulness, rapid-eye-movement (REM) and non-REM sleep). Alcoholics had a poorer subjective and objective sleep quality compared to controls. Across the night, alcoholic men and women had elevated heart rate, reduced total HRV, i.e. lower standard deviation of normal-to-normal inter-beat-intervals, and reduced high frequency activity (assessed by the high frequency power and by the square root of the mean squared of successive heart period differences). This ANS pattern was most apparent at the beginning of the night. None of the ANS measures was associated with lifetime alcohol consumption or duration of alcohol dependence. Our results show that ANS functioning is disrupted during the night, even in undisturbed sleep periods, indicating poor cardiovascular functioning in recently detoxified alcohol-dependent men and women.