Serum CEA and CA 15-3 as prognostic factors in primary breast cancer.
Serum CEA and CA 15-3 as prognostic factors in primary breast cancer.
复制标题
DOI：
10.1038/sj.bjc.6600248
复制
发表时间：
2002-04-22
影响因子：
8.8
通讯作者：
Seidel D
中科院分区：
文献类型：
--
作者：
Ebeling FG;Stieber P;Untch M;Nagel D;Konecny GE;Schmitt UM;Fateh-Moghadam A;Seidel D
在本研究中，我们调查了1046名女性乳腺癌患者的血清肿瘤标志物癌胚抗原和癌抗原15-3水平与无病生存和疾病死亡的关系，这些患者在初步诊断时没有转移，与年龄和既定的预后因素肿瘤大小、淋巴结状态、组织学分级和激素受体状态有关。我们发现，在单变量分析中，术前血清标志物值升高与早期复发（癌抗原15-3; P=0.0003）和疾病死亡（癌胚抗原，癌抗原15-3; P=0.0001）相关。通过比较术前和术后的值，我们发现术后的值有所下降。在单变量分析中，观察到癌胚抗原标志物水平下降超过33%的患者复发和疾病死亡的风险显著较高（均P=0.0001）。在多变量分析中，这种癌胚抗原的减少被证明是一个独立的预后因素。在单因素分析中，癌抗原15-3的结果与癌胚抗原相当，但在多因素分析中没有显示出显著性。在这项研究中，术后血清肿瘤标志物癌胚抗原的降低是乳腺癌患者无病生存和疾病死亡的一个强有力的独立预后因素。英国癌症杂志（2002）86，1217-1222。DOI：10.1038/sj/bjc/6600248 www.bjcancer.com © 2002英国癌症研究中心
In the present study, we investigated the association of the serum levels of the tumour markers carcinoembryonic antigen and cancer antigen 15-3 with disease free survival and death from disease in 1046 women with breast cancer without metastases at the time of primary diagnosis in relation to age and the established prognostic factors tumour size, lymph node status, histological grading and hormone receptor status. We found that elevated pre-operative serum marker values were correlated with early relapse (cancer antigen 15-3; P=0.0003) and death from disease (carcinoembryonic antigen, cancer antigen 15-3; P=0.0001 both) in univariate analyses. By comparing pre- and post-operative values we found a decline in values post-surgery. In those patients where marker levels of carcinoembryonic antigen decreased more than 33%, a significantly higher risk for relapse and death from disease (both P=0.0001) in univariate analyses was observed. In multivariate analysis this decrease of carcinoembryonic antigen proved to be an independent prognostic factor. The results for cancer antigen 15-3 were comparable to carcinoembryonic antigen in univariate analyses but showed no significance in multivariate analysis. In this study the post-operative decrease of the serum tumour marker carcinoembryonic antigen was a strong independent prognostic factor for disease free survival and death from disease in breast cancer patients. British Journal of Cancer (2002) 86, 1217–1222. DOI: 10.1038/sj/bjc/6600248 www.bjcancer.com © 2002 Cancer Research UK
登录
查看更多内容
影响因子：
3.3
作者：
Sundblad, AS;Pellicer, EM;Ricci, L
通讯作者：
Ricci, L
DOI：
10.1093/jnci/89.2.139
发表时间：
1997-01-15
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Gasparini, G;Toi, M;Tominaga, T
通讯作者：
Tominaga, T
影响因子：
8.8
作者：
GION, M;MIONE, R;BRUSCAGNIN, G
通讯作者：
BRUSCAGNIN, G
影响因子：
6.2
作者：
CONCANNON, JP;DALBOW, MH;LIEBLER, GA
通讯作者：
LIEBLER, GA
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P