Pesticides and other occupational exposures are associated with airway obstruction: the LifeLines cohort study
Pesticides and other occupational exposures are associated with airway obstruction: the LifeLines cohort study
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DOI：
10.1136/oemed-2013-101639
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发表时间：
2014-02-01
影响因子：
4.9
通讯作者：
Vonk, J. M.
中科院分区：
文献类型：
--
作者：
de Jong, K.;Boezen, H. M.;Vonk, J. M.
目标职业暴露是重要的，并且可能改变了慢性阻塞性肺部疾病（COPD）负担的全球负担。暴露于蒸气，气体，灰尘和烟雾（VGDF）与COPD风险高两到三倍有关。关于职业暴露于农药和溶剂的影响知之甚少。在当前的研究中，我们评估了VGDF，农药和溶剂是否与一般人群中的肺功能水平和气道阻塞的患病率有关。方法包括11851名来自Lifeelines coothort群体研究的89岁年龄的受试者。回归模型评估职业暴露（无/低/高），肺功能水平（胸骨前FEV1，FEV1/FVC）和轻度和中度/严重的气道阻塞的关联，以适应性别，身高，身高，体重，电流/EX-吸烟和packyears。此外，我们根据吸烟状况和性别进行了分层，并测试了相互作用。第二个普通人群（n = 2364）用于验证我们的初始发现。对VGDF和农药的职业暴露与较低的FEV1和FEV1和FEV1/FVC相关，并且较高的轻度和中度/严重气道的患病率较高在研究的两个一般人群中。没有与溶剂接触的关联。结论对VGDF和农药的识别与普通人群的气道阻塞有关。
Objectives Occupational exposures are important and possibly modifiable contributors to the global burden of chronic obstructive pulmonary disease (COPD). Exposure to vapours, gases, dusts and fumes (VGDF) has been associated with a two- to threefold higher COPD risk. Less is known about effects of occupational exposure to pesticides and solvents. In the current study, we assessed if VGDF, pesticides and solvents are associated with the level of lung function and the prevalence of airway obstruction in the general population.Methods We included 11 851 subjects aged 18 89 years from the LifeLines cohort study. Regression models assessing associations between occupational exposures (no/low/high), level of lung function (prebronchodilator FEV1, FEV1/FVC) and mild and moderate/severe airway obstruction were adjusted for sex, age, height, weight, current/ex-smoking and packyears. Additionally, we stratified by smoking status and gender and tested for interaction. A second general population cohort (n=2364) was used to verify our initial findings.Results Occupational exposure to VGDF and pesticides was associated with a lower level of FEV1 and FEV1/FVC and with a higher prevalence of mild and moderate/severe airway obstruction in the two general populations investigated. There were no associations with exposure to solvents.Conclusions Occupational exposure to both VGDF and pesticides is associated with airway obstruction in the general population.