TGF-β regulation of encephalitogenic and regulatory T cells in multiple sclerosis.
TGF-β regulation of encephalitogenic and regulatory T cells in multiple sclerosis.
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DOI：
10.1002/eji.201646716
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发表时间：
2017-03
影响因子：
5.4
通讯作者：
Lovett-Racke AE
中科院分区：
文献类型：
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作者：
Lee PW;Severin ME;Lovett-Racke AE
Transforming growth factor-beta (TGF-β) is a pleiotrophic cytokine that has been shown to influence the differentiation and function of T cells. As such, the role that TGF-β plays in immune-mediated disease, such as multiple sclerosis (MS), has become a major area of investigation since CD4 T cells appear to be a major mediator of the autoimmunity. This review analysis the literature on the role that TGF-β plays in the generation and regulation of encephalitogenic T cells in experimental autoimmune encephalomyelitis, an animal model of MS, as well as T cells of MS patients. Since TGF-β plays a major role in the development and function of CD4 regulatory T cells, which are defective in MS patients, recent studies have found potential mechanisms to explain the basis for these regulatory T cell defects to establish a foundation for potentially modulating TGF-β signaling to restore normal T cell function in MS patients.
