Regulation of Sympathetic and Parasympathetic Receptor Responses in the Rat Trachea by Epithelium: Influence of Mechanical and Chemical Removal of Epithelium
Regulation of Sympathetic and Parasympathetic Receptor Responses in the Rat Trachea by Epithelium: Influence of Mechanical and Chemical Removal of Epithelium
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上皮对大鼠气管交感和副交感受体反应的调节：机械和化学去除上皮的影响
DOI：
10.1111/j.2042-7158.1990.tb07035.x
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发表时间：
1990
影响因子：
3.3
通讯作者：
A. Bast
中科院分区：
文献类型：
--
作者：
C. Doelman;W. Oosterom;A. Bast
摘除大鼠气管组织上皮层不影响乙酰甲胆碱引起的气管平滑肌收缩，但减弱(-)-异丙肾上腺素引起的松弛(以乙酰胆碱收缩百分比表示)。通过这种方式，上皮层似乎在维持交感和副交感受体反应之间的自主神经平衡方面发挥了作用。大鼠气管组织与过氧化氢异丙苯(3×10−5~10−3 M)孵育后，上皮层被部分清除，并呈剂量依赖性破坏。过氧化氢异丙苯降低大鼠气管的M受体反应。此外，M受体反应和β受体反应之间的自主神经平衡也受到影响。去上皮后过氧化氢异丙苯对受体反应的影响更为明显。因此，强调了肺组织上皮层对氧化应激的保护作用。
Abstract— Removal of the epithelial layer of rat tracheal tissue did not affect the methacholine‐induced contraction of the tracheal smooth muscle, but attenuated the (—)‐isoprenaline induced relaxation (expressed as percentage of the methacholine contraction). In this way the epithelial layer seemed to play a role in the maintenance of an autonomic balance between sympathetic and parasympathetic receptor responses. Incubation of rat tracheal tissue with cumene hydroperoxide (3 × 10−5‐10−3 M) resulted in a dose‐dependent destruction and (partial) removal of the epithelial layer. Cumene hydroperoxide diminished muscarinic receptor responses of the rat trachea. Moreover, the autonomic balance between muscarinic and β‐adrenoceptor responses was affected. The effects of cumene hydroperoxide on receptor responses were more pronounced after epithelium removal. The protective role of the epithelial layer of pulmonary tissue against oxidative stress has therefore been emphasized.
DOI：
10.1152/jappl.1987.63.6.2510
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Stuart-Smith,K;Vanhoutte,PM
通讯作者：
Vanhoutte,PM
哮喘患者中性粒细胞中超氧化物的产生及其腺苷的调节。
DOI：
10.1016/0091-6749(89)90112-7
发表时间：
1989
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Meltzer,S;Goldberg,B;Lad,P;Easton,J
通讯作者：
Easton,J
上皮源性舒张因子和支气管反应性。
DOI：
10.1016/0091-6749(89)90095-x
发表时间：
1989
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Vanhoutte,PM
通讯作者：
Vanhoutte,PM