Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome.
Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome.
复制标题
DOI：
10.1155/2015/638470
复制
发表时间：
2015
影响因子：
4.6
通讯作者：
Chu CQ
中科院分区：
文献类型：
--
作者：
Li Y;Liu Y;Chu CQ
1型糖尿病（T1D）是一种自身免疫性疾病，其特征在于产生胰岛素的胰岛β细胞的进行性破坏。发展T1D的风险由遗传和环境因素决定。越来越多的证据支持辅助性T细胞17型（Th17）细胞沿着受损的调节性T细胞（Treg）在动物模型和人类T1D的发展中的重要作用。肠道微生物群的改变被认为是Th17和Treg细胞之间失衡的原因。然而，在肠道微生物群影响的背景下，关于Th17细胞在糖尿病小鼠模型中的致病作用与保护作用存在争议。在这篇综述中，我们将总结目前有关Th17细胞和肠道微生物群参与T1D的知识，并提出Th17靶向治疗胰岛自身免疫儿童，以防止进展为显性糖尿病。
Type 1 diabetes (T1D) is an autoimmune disease which is characterized by progressive destruction of insulin producing pancreatic islet β cells. The risk of developing T1D is determined by both genetic and environmental factors. A growing body of evidence supports an important role of T helper type 17 (Th17) cells along with impaired T regulatory (Treg) cells in the development of T1D in animal models and humans. Alteration of gut microbiota has been implicated to be responsible for the imbalance between Th17 and Treg cells. However, there is controversy concerning a pathogenic versus protective role of Th17 cells in murine models of diabetes in the context of influence of gut microbiota. In this review we will summarize current knowledge about Th17 cells and gut microbiota involved in T1D and propose Th17 targeted therapy in children with islet autoimmunity to prevent progression to overt diabetes.