Mx oligomer: a novel capsid pattern sensor?
Mx oligomer: a novel capsid pattern sensor?
复制标题
Mx 寡聚物：一种新型衣壳模式传感器？
DOI：
10.2217/fmb-2016-0004
复制
发表时间：
2016-08-01
影响因子：
3.1
通讯作者：
Qin, Xiaohong
中科院分区：
文献类型：
--
作者：
Kong, Jia;Ma, Min;Qin, Xiaohong
粘病毒抗性蛋白代表先天性和适应性免疫系统的干扰素诱导的限制因子家族。人MxB作为一种新的限制因子，主要通过抑制逆转录后但整合前的脱壳过程，对一系列HIV-1和其他逆转录病毒具有抗病毒活性。基于已发表的数据和保守性分析，我们提出了一个新的假设，其中MxB二聚体形成更高阶的寡聚体，通过与病毒衣壳结合来限制逆转录病毒的复制。深入了解MxB的结构和功能特征的机制基础将大大促进我们对MxB的理解。
Myxovirus resistance proteins represent a family of interferon-induced restriction factors of the innate and adaptive immune system. Human MxB acts as a novel restriction factor with antiviral activity against a range of HIV-1 and other retroviruses mainly by inhibiting the uncoating process after reverse transcription but prior to integration. Based on published data and conservation analysis, we propose a novel hypothesis, in which MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. Insights into the mechanistic basis of structural and functional characteristics of MxB will greatly advance our understanding of MxB.