Functions of Shp2 in cancer.
Functions of Shp2 in cancer.
复制标题
Shp2 在癌症中的功能
DOI：
10.1111/jcmm.12618
复制
发表时间：
2015-09
影响因子：
5.3
通讯作者：
Niu R
中科院分区：
文献类型：
--
作者：
Zhang J;Zhang F;Niu R
诊断和治疗显示出明显的进步。肿瘤手术、化疗和放射治疗是治疗癌症的主要手段。靶向治疗和耐药是肿瘤研究的主要热点，但许多分子细胞内机制尚不清楚。SRC同源区蛋白酪氨酸磷酸酶2(Shp2)与乳腺癌、白血病、肺癌、肝癌、胃癌、喉癌、口腔癌等多种癌症类型相关。还发现了涉及Shp2的信号通路。Shp2与多种疾病有关。PTPN11基因突变会导致努南综合征、豹子综合征和儿童白血病。Shp2还参与多种肿瘤相关过程，包括癌细胞侵袭转移、细胞凋亡、DNA损伤、细胞增殖、细胞周期和耐药等。基于Shp2的结构和功能，科学家们研究了与癌症有关的具体机制。Shp2可能是一个潜在的治疗靶点，因为这种磷酸酶参与了许多方面的研究。此外，Shp2抑制剂已被用于实验，以开发治疗策略。然而，文献中出现了与Shp2功能相关的相互矛盾的结果，这些结果需要在未来的研究中得到解决。
Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug resistance are the main focus in cancer research, but many molecular intracellular mechanisms remain unknown. Src homology region 2‐containing protein tyrosine phosphatase 2 (Shp2) is associated with breast cancer, leukaemia, lung cancer, liver cancer, gastric cancer, laryngeal cancer, oral cancer and other cancer types. Signalling pathways involving Shp2 have also been discovered. Shp2 is related to many diseases. Mutations in the ptpn11 gene cause Noonan syndrome, LEOPARD syndrome and childhood leukaemia. Shp2 is also involved in several cancer‐related processes, including cancer cell invasion and metastasis, apoptosis, DNA damage, cell proliferation, cell cycle and drug resistance. Based on the structure and function of Shp2, scientists have investigated specific mechanisms involved in cancer. Shp2 may be a potential therapeutic target because this phosphatase is implicated in many aspects. Furthermore, Shp2 inhibitors have been used in experiments to develop treatment strategies. However, conflicting results related to Shp2 functions have been presented in the literature, and such results should be resolved in future studies.