Epilepsy after head injury: An overview
Epilepsy after head injury: An overview
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DOI：
10.1111/j.1528-1167.2008.02004.x
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发表时间：
2009-01-01
期刊：
影响因子：
5.6
通讯作者：
Lowenstein, Daniel H.
中科院分区：
文献类型：
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作者：
Lowenstein, Daniel H.
创伤性脑损伤（TBI）自古以来就被认为是癫痫的原因之一，并且它仍然是当今获得性癫痫最常见和最重要的原因之一。流行病学研究表明，损伤的严重程度与癫痫发生的可能性之间存在明确的关系，在与脑实质直接损伤相关的TBI病例中，风险接近50%。重要的是，许多TBI患者在最初损伤后数月或数年发生癫痫，这使得该患者群体成为抗癫痫治疗发展的主要目标。然而，由于缺乏可靠和有效的生物标志物，这一临床研究领域的进展受到阻碍。鉴于中东和其他地区的当前事件，由于与现代战争相关的严重头部创伤的增加，TBI和癫痫的重要性值得特别关注。
Traumatic brain injury (TBI) has been recognized as a cause of epilepsy since antiquity, and it remains one of the most common and important causes of acquired epilepsy today. Epidemiologic studies have demonstrated a clear relationship between the severity of injury and the likelihood of developing epilepsy, with the risk approaching 50% in TBI cases associated with direct injury to brain parenchyma. Importantly, many TBI victims develop epilepsy months or years following the initial injury, making this patient population a prime target for the development of antiepileptogenesis therapies. However, progress in this area of clinical research is hindered by the lack of reliable and valid biomarkers. Given current events in the Middle East and elsewhere, the importance of TBI and epilepsy deserves special attention due to the increase in severe head trauma associated with modern warfare.