Adaptogenic activity of Withania somnifera:: an experimental study using a rat model of chronic stress
Adaptogenic activity of Withania somnifera:: an experimental study using a rat model of chronic stress
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DOI：
10.1016/s0091-3057(03)00110-2
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发表时间：
2003-06-01
影响因子：
3.6
通讯作者：
Muruganandam, AV
中科院分区：
文献类型：
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作者：
Bhattacharya, SK;Muruganandam, AV
Withania somnifera（WS）Dunal在古印度医学系统Ayurveda中被归类为rasayana，一组植物衍生药物，被认为可以促进身心健康，增强身体对疾病和各种不利环境因素的抵抗力，在虚弱的条件下恢复身体活力并延长寿命。这些属性与现代医学中的人参（PG）等适应原的属性非常相似。因此，WS根的标准化提取物的适应原活性针对慢性应激（CS）的大鼠模型进行了研究。应激程序为轻度、不可预测的足电击，对成年雄性Wistar大鼠每日给药一次，持续21天。CS诱导显著的高血糖、葡萄糖耐受不良、血浆皮质酮水平升高、胃溃疡、男性性功能障碍、认知缺陷、免疫抑制和精神抑郁。足电击前1 h给予WS（25和50 mg/kg po）和PG（100 mg/kg po），持续21天，可减弱CS诱导的这些扰动。结果表明，WS，如PG，具有显着的抗应激适应活性，证实了该植物在阿育吠陀的临床应用。(C)2003年爱思唯尔科学公司All rights reserved.
Withania somnifera (WS) Dunal is classified in Ayurveda, the ancient Hindu system of medicine, as a rasayana, a group of plant-derived drugs reputed to promote physical and mental health, augment resistance of the body against disease and diverse adverse environmental factors, revitalise the body in debilitated conditions and increase longevity. These attributes are remarkably similar to the properties ascribed to adaptogens like Panax ginseng (PG) in contemporary medicine. As such, the adaptogenic activity of a standardised extract of WS roots was investigated against a rat model of chronic stress (CS). The stress procedure was mild, unpredictable footshock, administered once daily for 21 days to adult male Wistar rats. CS induced significant hyperglycaemia, glucose intolerance, increase in plasma corticosterone levels, gastric ulcerations, male sexual dysfunction, cognitive deficits, immunosuppression and mental depression. These CS induced perturbations were attenuated by WS (25 and 50 mg/kg po) and by PG (100 mg/kg po), administered 1 h before footshock for 21 days. The results indicate that WS, like PG, has significant antistress adaptogenic activity, confirming the clinical use of the plant in Ayurveda. (C) 2003 Elsevier Science Inc. All rights reserved.