Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.
Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.
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DOI：
10.1182/blood.v80.5.1105.bloodjournal8051105
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发表时间：
1992-09
期刊：
影响因子：
20.3
通讯作者：
D. Greenwalt;Robert Lipsky;C. Ockenhouse;H. Ikeda;N. Tandon;G. Jamieson
中科院分区：
文献类型：
--
作者：
D. Greenwalt;Robert Lipsky;C. Ockenhouse;H. Ikeda;N. Tandon;G. Jamieson
在首次鉴定时，血小板糖蛋白w GPIV显示出对蛋白酶消化的显著抗性。随后显示在骨髓增生性疾病中相对增加。3 ~~最近，有大量的信息表明GPIV与白细胞分化抗原CD 36相同，后者存在于广泛的细胞和组织中，并且在粘附现象、信号转导和血液病理学中起主要作用。此外，它与CD 36相关蛋白LIMP 11一起，可能是迄今尚未认识到的受体分子家族的成员。本综述的目的是总结目前的知识状况的CD 36，这是通用的术语，我们将在本次审查中使用的这一重要的糖蛋白。CD 36也被称为GP 88：GPIIb，6和PAS
EN IT WAS first identified, platelet glycoprotein w GPIV was shown to have a remarkable resistance to protease digestion.'S2 It was subsequently shown to be relatively increased in myeloproliferative disorders.3~~ More recently, there has been an explosion of information which has shown that GPIV is identical with the leukocyte differentiation antigen CD36, which occurs in a wide range of cells and tissues, and that it plays major roles in adhesion phenomena, signal transduction, and hematopathology. Furthermore, it, together with the CD36-related protein LIMP 11, may be a member of a hitherto-unrecognized family of receptor molecules. The purpose of the present review is to summarize the current status of knowledge of CD36, which is the generic term we will use in this review for this important glycoprotein. CD36 has also been termed GP88: GPIIIb,6 and PAS