Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice.
Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice.
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在癌细胞代谢中解码关键节点：糖和香料以及所有事物。
DOI：
10.3410/b4-2
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Cantley LC
中科院分区：
文献类型：
--
作者：
Shaw RJ;Cantley LC
在过去的5年中，研究的融合导致了癌症研究界的广泛认识，即细胞代谢的重新编程可能比过去30年所认识到的对癌症更重要。癌症新陈代谢的重新出现部分源于一些常见的癌基因和肿瘤抑制基因比之前认为的更直接地控制细胞新陈代谢的发现。此外，许多以前被称为“携带卡片”的代谢酶已被确认为人类肿瘤抑制基因或癌基因，在各种人类癌症中发生了因果突变。随着人们对细胞代谢改变作用的日益认识，对参与肿瘤细胞独特代谢不同方面的限速蛋白进行了进一步的研究。用药物靶向癌症代谢需要一个治疗窗口，在这个窗口中，与正常组织相比，肿瘤细胞对特定代谢酶有更大的依赖。在过去十年开发癌基因靶向癌症疗法的过程中出现的主题表明，具有不同致癌损害的肿瘤可能需要针对不同代谢途径的药物。最终，人们希望，对癌基因和抑癌基因功能及其对新陈代谢的影响的详细了解，将导致治疗癌症的药物组合将有效得多。
In the past 5 years, a convergence of studies has resulted in a broad appreciation in the cancer research community that reprogramming of cellular metabolism may be more central to cancer than appreciated in the past 30 years. The re-emergence of cancer metabolism stems in part from discoveries that a number of common oncogenes and tumor suppressor genes more directly control cell metabolism than previously thought. In addition, a number of what would previously have been called “card-carrying” metabolic enzymes have been identified as human tumor suppressors or oncogenes, causally mutated in a variety of human cancers. This growing appreciation of the role of altered cell metabolism has led to further investigation into the rate-limiting proteins involved in different aspects of the unique metabolism of tumor cells. Targeting cancer metabolism with drugs requires a therapeutic window in which tumor cells, compared to normal tissues, have a greater dependence on specific metabolic enzymes. Themes that have emerged in the past decade of developing oncogene-targeted cancer therapeutics suggest that tumors with distinct oncogenic lesions are likely to require drugs that target distinct metabolic pathways. Ultimately, the hope is that detailed knowledge of oncogene and tumor suppressor gene functions and their effects on metabolism will lead to drug combinations that will be far more effective in treating cancers.