How 'love' and 'hate' differ from 'sleep': Using combined electro/magnetoencephalographic data to reveal the sources of early cortical responses to emotional words
How 'love' and 'hate' differ from 'sleep': Using combined electro/magnetoencephalographic data to reveal the sources of early cortical responses to emotional words
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DOI：
10.1002/hbm.22220
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发表时间：
2014-03-01
影响因子：
4.8
通讯作者：
Dobel, Christian
中科院分区：
文献类型：
--
作者：
Keuper, Kati;Zwanzger, Peter;Dobel, Christian
情感词汇作为生物学相关概念的符号，优先在大脑区域处理，包括视觉皮层、额叶和顶叶区域，以及包括杏仁核在内的皮质边缘回路。在功能性磁共振成像中发现的一些大脑结构在脑电图和脑磁图（EEG; MEG）测量中并不明显。通过组合EEG/MEG源定位程序，以充分利用现有的信息，我们试图减少这些差异，并获得更好地了解时空大脑动力学的情绪文字处理。18名受试者阅读高唤起的积极和消极的，和低唤起的中性名词，同时记录EEG和MEG。结合电流密度重建（L2-最小范数最小二乘法）的两个早期情绪敏感的时间间隔，P1（80-120毫秒）和早期后负波（EPN，200-300毫秒），计算使用现实的个人头部模型与皮质约束。P1时间窗揭示了情绪效应在左颞中回达到峰值。在EPN的时间窗口，处理情绪的话与增强活动，包括顶叶和枕叶区，和后边缘结构。我们建议，词汇访问，正在进行中的100毫秒内，加快和/或有利于情感词，可能是在收购过程中的单词形式的“情感标签”的基础上。这导致它们在EPN时间窗口中的差分处理。EPN作为自然选择性注意的指标，似乎反映了与认知功能（如记忆、注意和情绪刺激评价）相关的分布式结构的复杂相互作用。《脑地图》35：875-888，2014年。(c)2012 Wiley Periodicals，Inc.
Emotional words-as symbols for biologically relevant concepts-are preferentially processed in brain regions including the visual cortex, frontal and parietal regions, and a corticolimbic circuit including the amygdala. Some of the brain structures found in functional magnetic resonance imaging are not readily apparent in electro- and magnetoencephalographic (EEG; MEG) measures. By means of a combined EEG/MEG source localization procedure to fully exploit the available information, we sought to reduce these discrepancies and gain a better understanding of spatiotemporal brain dynamics underlying emotional-word processing. Eighteen participants read high-arousing positive and negative, and low-arousing neutral nouns, while EEG and MEG were recorded simultaneously. Combined current-density reconstructions (L2-minimum norm least squares) for two early emotion-sensitive time intervals, the P1 (80-120 ms) and the early posterior negativity (EPN, 200-300 ms), were computed using realistic individual head models with a cortical constraint. The P1 time window uncovered an emotion effect peaking in the left middle temporal gyrus. In the EPN time window, processing of emotional words was associated with enhanced activity encompassing parietal and occipital areas, and posterior limbic structures. We suggest that lexical access, being underway within 100 ms, is speeded and/or favored for emotional words, possibly on the basis of an "emotional tagging" of the word form during acquisition. This gives rise to their differential processing in the EPN time window. The EPN, as an index of natural selective attention, appears to reflect an elaborate interplay of distributed structures, related to cognitive functions, such as memory, attention, and evaluation of emotional stimuli. Hum Brain Mapp 35:875-888, 2014. (c) 2012 Wiley Periodicals, Inc.