SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes
SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes
复制标题
DOI：
10.1016/j.diabres.2006.03.030
复制
发表时间：
2006-12-01
影响因子：
5.1
通讯作者：
Seino, Yutaka
中科院分区：
文献类型：
--
作者：
Yamada, Yuichiro;Fukuda, Kazuhito;Seino, Yutaka
评估患者的胰腺β细胞功能在糖尿病的诊断和治疗中都是重要的。我们试图通过单次血液采样来确定β细胞功能。四名患者的七个胰岛移植后状态的空腹血糖（F-BG，mM）和C肽（FCPR，nM）水平的检查显示F-BG和F-CPR之间的线性关系。假设年龄< 40岁的正常受试者具有100%的胰腺β细胞功能，我们通过公式：250 x F-CPR/（F-BG - 3.43）开发了移植中胰岛分泌单位（SUIT）作为β细胞功能的指数。SUIT指数与刺激C肽水平不仅在胰岛移植组（R-2 = 0.68，P < 0.05），而且在2型糖尿病患者（R-2 = 0.34，P < 0.001）也存在相关性。由于SUIT指数可以从单次空腹采血获得的数据计算并预测胰腺β细胞功能，因此该公式可能是糖尿病临床管理的有用工具。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Evaluation of a patient's pancreatic beta-cell function is important in both diagnosis and treatment of diabetes. We sought to determine beta-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (FCPR, nM) levels in seven post-islet-transplanted states of four patients revealed a linear relationship between F-BG and F-CPR. Assuming that normal subjects aged < 40 years have 100% pancreatic beta-cell function, we developed the secretory units of islets in transplantation (SUIT) as an index of beta-cell function by the formula: 250 x F-CPR/(F-BG - 3.43). The SUIT index was correlated with the stimulated C-peptide levels not only in islet-transplanted patients (R-2 = 0.68, P < 0.05) but also in type 2 patients (R-2 = 0.34, P < 0.001). Since the SUIT index can be calculated from data obtained at a single fasting blood sampling and predict the pancreatic beta-cell function, the formula may be a useful tool in clinical management of diabetes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.