Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting
Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting
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中空二氧化硅纳米胶囊的可逆孔结构演化：用于 siRNA 递送和纳米颗粒收集的大孔
DOI：
10.1002/smll.201101055
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发表时间：
2011-10-17
期刊：
影响因子：
13.3
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Chen, Yu;Chu, Chen;Shi, Jianlin
纳米多孔二氧化硅纳米粒子的孔径的有效调节仍然是一个尚未令人满意地解决的巨大挑战。在本文中，中空二氧化硅纳米胶囊的壳中的孔径是很好的调整，通过可逆的Si-O键断裂和重组过程中，在温和的碱性条件下（例如，）。例如，在一个实施例中，Na 2CO 3溶液）。通过一种新的表面活性剂导向碱蚀刻（SDAE）策略，可以将纳米级中空二氧化硅胶囊中的孔从3.2 nm调制到大于10 nm。有趣的是，通过与壁表面上的硅烷醇（Si-OH）键合，溶解的硅酸盐的再生长可以完全填充孔，以产生无孔中空二氧化硅纳米胶囊。该大孔空心二氧化硅纳米胶囊在体外表现出优异的siRNA负载能力和细胞内转染效率。此外，在空心二氧化硅纳米胶囊壳的大孔探索作为通道收集超顺磁性，小尺寸的Fe 3 O 4纳米粒子作为磁共振成像的造影剂，启动一个特殊的方法对孔径调制和多功能化的二氧化硅基纳米结构材料的纳米生物医学应用。
The effective modulation of pore sizes for nanoporous silica nanoparticles still remains a great challenge not satisfactorily solved. In this paper, the pore sizes in the shell of hollow silica nanocapsules are well-tuned by a reversible Si-O bond breakage and reformation process under mildly alkaline conditions (e. g., Na2CO3 solution). The pores in nanosized hollow silica capsules can be modulated from 3.2 nm to larger than 10 nm by a novel, surfactant-directing alkaline-etching (SDAE) strategy. Interestingly, the pores can be fully filled through the regrowth of the dissoluted silicates by bonding to silanols (Si-OH) on the wall surface to generate the nonporous hollow silica nanocapsules. The large-sized pore hollow silica nanocapsules exhibit excellent siRNA-loading capabilities and intracellular transfection efficiencies in vitro. In addition, the large pores in the shell of hollow silica nanocapsules are explored as channels for collecting superparamagnetic, small-sized Fe3O4 nanoparticles as contrast agents for magnetic resonance imaging, initiating a special approach towards pore-size modulation and multifunctionalization of silica-based nanostructural materials for nanobiomedical applications.