23Na, 59Co and 2H NMR studies of experimental acute pancreatitis.
23Na, 59Co and 2H NMR studies of experimental acute pancreatitis.
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实验性急性胰腺炎的 23Na、59Co 和 2H NMR 研究。
DOI：
10.1002/nbm.1940040405
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发表时间：
1991
影响因子：
2.9
通讯作者：
Navon,G
中科院分区：
文献类型：
--
作者：
Kushnir,T;Kaplan,O;Askenasy,N;Navon,G
多核磁共振应用于实验性急性胰腺炎的研究。在从水肿阶段到坏死的疾病发展过程中，检测到总钠含量持续增加，高达 700%。疾病期间23 Na NMR可见度的增加放大了钠含量升高的影响。分别通过 50 Co和 2 H NMR，使用Co(CN) 36 和D 2 O的分布来估计胰腺的间质水体积和总水体积。在健康的胰腺中，间质室占组织体积的 35%。在病变胰腺中，Co(CN)36的渗透体积达到组织总体积的90%，表明存在广泛的膜损伤。在位移试剂Na 7 Dy(三聚磷酸) 2.3 NaCl存在下23 Na NMR的时间依赖性提供了患病器官中膜的渗透性增加的额外证据。
Multinuclear MR was applied to the study of experimental acute pancreatitis. A continuous increase, up to 700%, of total, NMR visible, sodium content was detected during the development of the disease through the edematous stage to necrosis. The effect of the elevation of sodium content is amplified by an increased23Na NMR visibility during the disease. Interstitial and total water volume of pancreases were estimated using the distribution of Co(CN)36and D2O, by50Co and2H NMR, respectively. In healthy pancreases the interstitial compartment was found to comprise 35% of the tissue volume. In the diseased pancreases the penetration volume of Co(CN)36reached 90% of the total tissue volume, indicating extensive membrane injury. The time dependence of the23Na NMR in the presence of the shift reagent Na7Dy(tripolyphosphate)2.3NaCl provided additional evidence of the increased permeability of the membranes in the diseased organs.