In utero and postnatal maternal smoking and asthma in adolescence
In utero and postnatal maternal smoking and asthma in adolescence
复制标题
DOI：
10.1097/01.ede.0000198148.02347.33
复制
发表时间：
2006-03-01
期刊：
影响因子：
5.4
通讯作者：
Williams, GM
中科院分区：
文献类型：
--
作者：
Alati, R;Al Mamun, A;Williams, GM
背景：儿童早期哮喘与母亲孕期吸烟以及孩子出生后父母吸烟有关。然而，对于这些暴露因素与青少年哮喘症状的发展之间的关系，人们知之甚少。
方法：数据来自于“马特大学妊娠研究”，这是一项始于1981年在澳大利亚布里斯班对母亲和儿童进行的大型出生队列研究。在孕期的两个阶段以及6个月和5年的随访中对吸烟情况进行了评估。在孩子14岁时，根据母亲的报告对哮喘进行了评估。我们进行了多变量多项逻辑回归分析，以评估母亲吸烟对哮喘症状的影响。
结果：存在明显的性别交互作用，母亲在孕期和6个月随访时大量吸烟（每天20支或更多）的女孩在14岁时出现哮喘症状的几率增加（比值比 = 1.96；95%置信区间 = 1.25 - 3.08）。孕期大量吸烟的影响似乎比出生后大量吸烟更强。在男孩中未发现类似的关联。
结论：母亲在胎儿期和孩子出生后早期大量吸烟的女性青少年在青春期出现哮喘症状的风险增加。研究发现，宫内大量吸烟暴露比出生后的环境烟草暴露影响更强。
Background: Asthma in early childhood has been associated with maternal smoking during pregnancy and parental smoking soon after birth. However, less is known about these exposures and the development of asthma symptoms in adolescence.Methods: Data were taken from the Mater University Study, of Pregnancy, a large birth cohort study of mothers and children enrolled in Brisbane, Australia, beginning in 1981. Smoking was assessed at 2 stages during pregnancy and at the 6-month and 5-year follow-up visits. Asthma was assessed from maternal reports that were provided when the child was age 14 years. We conducted multivariable multinomial logistic regression analyses to assess the effect of maternal smoking on asthma symptoms.Results: There was a strong sex interaction such that girls whose mothers had smoked heavily (20 or more cigarettes per day) in pregnancy and at the 6-month follow up had increased odds of experiencing asthma symptoms at age 14 (odds ratio = 1.96; 95% confidence interval = 1.25-3.08). The contribution of heavy smoking during pregnancy appeared to be stronger than heavy smoking after the birth. No similar associations were seen for boys.Conclusion: Female adolescents whose mothers smoked heavily during the fetal period and the early months of life have increased risk of asthma symptoms in adolescence. In utero exposure to heavy smoking was found to have a stronger effect than postnatal environmental tobacco exposure.