The Effects and Underlying Mechanisms of Cell Therapy on Blood-Brain Barrier Integrity After Ischemic Stroke.
The Effects and Underlying Mechanisms of Cell Therapy on Blood-Brain Barrier Integrity After Ischemic Stroke.
复制标题
细胞疗法对缺血性中风后血脑屏障完整性的影响和潜在机制。
DOI：
10.2174/1570159x18666200914162013
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发表时间：
2020
影响因子：
5.3
通讯作者：
Manaenko A
中科院分区：
文献类型：
--
作者：
Gao L;Song Z;Mi J;Hou P;Xie C;Shi J;Li Y;Manaenko A
缺血性中风是世界范围内死亡和残疾的主要原因之一。然而，仍然缺乏有效的治疗策略。以干/祖细胞为基础的治疗方法以其强大的优势成为治疗缺血性脑卒中的一种很有前途的手段。其机制涉及新的神经细胞和神经元回路的形成、抗氧化、减轻炎症、血管生成和促进神经发生。在过去的几十年中，深入的研究表明，细胞治疗可以促进血管稳定和减少缺血性卒中后血脑屏障（BBB）渗漏。然而，移植细胞在缺血性脑卒中中对血脑屏障完整性的影响及其机制尚未见报道。现就细胞治疗对缺血性脑卒中后血脑屏障完整性影响的研究进展及其机制作一综述。首先，我们将对缺血条件下血脑屏障功能障碍和细胞移植治疗缺血的概述。然后，我们将总结和讨论目前的知识，对缺血性卒中后BBB完整性的细胞治疗的影响和潜在的机制。特别是，我们将回顾最新的研究，在组织纤溶酶原激活剂（t-PA）介导的治疗和糖尿病脑卒中的细胞治疗和血脑屏障之间的关系。
Ischemic stroke is one of the main causes of mortality and disability worldwide. However, efficient therapeutic strategies are still lacking. Stem/progenitor cell-based therapy, with its vigorous advantages, has emerged as a promising tool for the treatment of ischemic stroke. The mechanisms involve new neural cells and neuronal circuitry formation, antioxidation, inflammation alleviation, angiogenesis, and neurogenesis promotion. In the past decades, in-depth studies have suggested that cell therapy could promote vascular stabilization and decrease blood-brain barrier (BBB) leakage after ischemic stroke. However, the effects and underlying mechanisms on BBB integrity induced by the engrafted cells in ischemic stroke have not been reviewed yet. Herein, we will update the progress in research on the effects of cell therapy on BBB integrity after ischemic stroke and review the underlying mechanisms. First, we will present an overview of BBB dysfunction under the ischemic condition and cells engraftment for ischemic treatment. Then, we will summarize and discuss the current knowledge about the effects and underlying mechanisms of cell therapy on BBB integrity after ischemic stroke. In particular, we will review the most recent studies in regard to the relationship between cell therapy and BBB in tissue plasminogen activator (t-PA)-mediated therapy and diabetic stroke.
影响因子：
3.7
作者：
Yan T;Ye X;Chopp M;Zacharek A;Ning R;Venkat P;Roberts C;Lu M;Chen J
通讯作者：
Chen J