[Control of the survival/apoptosis balance by E-cadherin: role in enterocyte anoikis].
[Control of the survival/apoptosis balance by E-cadherin: role in enterocyte anoikis].
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发表时间：
2004
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通讯作者：
Stéphane Fouquet;Verónica-Haydée Lugo-Martínez;J. Chambaz;P. Cardot;M. Pinçon-Raymond;S. Thenet
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作者：
Stéphane Fouquet;Verónica-Haydée Lugo-Martínez;J. Chambaz;P. Cardot;M. Pinçon-Raymond;S. Thenet
钙粘蛋白是参与细胞间粘附的跨膜糖蛋白。最近的发展表明，经典的钙粘蛋白可能作为粘附激活的信号受体。在这里，我们回顾了最近的数据，从文献中关于经典钙粘蛋白的作用，在控制细胞的生存和参与的信号通路。我们专注于命运和作用的E-钙粘蛋白，主要经典的上皮细胞中表达的钙粘蛋白，在细胞死亡程序中触发的细胞外基质（失巢凋亡）的锚定损失在肠上皮细胞。这些数据为这种蛋白质的关键作用开辟了新的视角，这种蛋白质在大多数癌症中失调，被认为是肿瘤抑制因子。
Cadherins are transmembrane glycoproteins involved in cell-cell adherence. Recent developments indicate that classical cadherins may act as adherence-activated signaling receptors. Here, we review recent data from the literature concerning the role of classical cadherins in the control of cell survival and the signaling pathways involved. We focus on the fate and the role of E-cadherin, the main classical cadherin expressed in epithelial cells, in the cell death program triggered in enterocytes by loss of anchorage from the extracellular matrix (anoikis). These data open new perspectives on the key role of this protein, which is dysregulated in most carcinoma and is considered as a tumour-suppressor.