Potassium transport: From clearance to channels and pumps
Potassium transport: From clearance to channels and pumps
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DOI：
10.1038/ki.1996.236
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发表时间：
1996-06-01
影响因子：
19.6
通讯作者：
Wang, WH
中科院分区：
文献类型：
--
作者：
Giebisch, G;Wang, WH
钾（K）稳态依赖于细胞内和细胞外液体室之间K分布的独立和相互关联的调节以及足够的肾脏排泄。本文主要综述了钾离子在体内分布的调节和钾离子处理的肾脏机制。基于清除率，微穿刺，和微灌注研究，大量的证据支持的观点，正常情况下，肾分泌的K决定排泄，并在初始和皮质集合小管中的主小管细胞分泌K，而K重吸收可能发生在闰细胞。电化学驱动力的研究，细胞内离子的活动，几种ATP酶的表征，和膜片钳研究提供了深入了解的作用，在这些小管细胞中的泵和通道，调节钾的分泌和重吸收。
Potassium (K) homeostasis depends on the separate and interrelated regulation of K distribution between the intra- and extra-cellular fluid compartments and adequate renal excretion. This brief review focuses on the regulation of internal K distribution and the renal mechanisms of K handling. Based on clearance, micropuncture, and microperfusion studies, a large body of evidence supports the view that normally, renal secretion of K determines excretion and that the principal tubule cells in the initial and cortical collecting tubule secrete K, whereas K reabsorption may occur in intercalated cells. Studies of the electrochemical driving forces, of intracellular ion activities, the characterization of several ATPases, and patch clamp investigations have provided insight into the role of pumps and channels in those tubule cells that regulate K secretion and reabsorption.