Staphylococcal Drp35 is the functional counterpart of the eukaryotic PONs
Staphylococcal Drp35 is the functional counterpart of the eukaryotic PONs
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DOI：
10.1016/j.femsle.2005.06.038
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发表时间：
2005-08-01
影响因子：
2.1
通讯作者：
Ohta, T
中科院分区：
文献类型：
--
作者：
Morikawa, K;Hidaka, T;Ohta, T
Drp35已被鉴定为金黄色葡萄球菌中响应于暴露于某些抗生素而诱导的蛋白质。在这里，我们证明，Drp35是一种内酯酶，不直接有助于诱导抗生素的耐药性，除了杆菌肽。对Drp35表达的详细分析表明，除了广泛的抗生素外，干扰膜完整性的试剂如去污剂也可以诱导其表达。这种特征表达的意义进行了讨论，其活性相似的真核生物的对应物，对氧磷酶家族蛋白。(c)2005年，欧洲微生物学会联合会。Elsevier B.V.出版，保留所有权利。
Drp35 has been identified as a protein that is induced in Staphylococcus aureus in response to exposure to certain antibiotics. Here we demonstrate that Drp35 is a lactonase that does not contribute directly to the resistance to the inducer antibiotics except for bacitracin. The detailed analysis on the expression of Drp35 revealed that in addition to a broad range of antibiotics, agents such as detergents that perturb the membrane integrity could induce its expression. The significance of this characteristic expression is discussed in relation to its activity similarity to the eukaryotic Counterparts, paraoxonase family proteins. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.