Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription
Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription
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DOI：
10.1073/pnas.0900162106
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发表时间：
2009-08-25
影响因子：
11.1
通讯作者：
Acker, Joel
中科院分区：
文献类型：
--
作者：
Tavenet, Arounie;Suleau, Audrey;Acker, Joel
人类PC4和酵母同源物Sub1在RNA聚合酶II转录中具有多种功能。全基因组图谱显示，Sub1存在于Pol iii转录基因上。发现Sub1与Pol III转录系统的组分相互作用，并在由所有重组因子重组的系统中刺激起始和再起始步骤。在指数生长的细胞中，Pol III基因的最佳转录需要Sub1。
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.