Frontal lobe dysfunction in Parkinson's disease: prognostic value for dementia?
Frontal lobe dysfunction in Parkinson's disease: prognostic value for dementia?
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DOI：
10.1159/000116381
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发表时间：
1989
影响因子：
2.4
通讯作者：
M. Piccirilli;P. D'alessandro;G. Finali;Luigi Piccinin;L. Agostini
中科院分区：
文献类型：
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作者：
M. Piccirilli;P. D'alessandro;G. Finali;Luigi Piccinin;L. Agostini
这项纵向研究的目的是调查是否存在额叶运动缺陷的帕金森病患者没有全球智力障碍的迹象可能有一个渐进性痴呆过程中的疾病过程中的发展预测价值。对30名没有任何一般智力障碍迹象的帕金森病患者进行了一项高级运动组织检查，使用的技能被认为取决于额叶区域的完整性。根据他们的表现，与对照组相比，他们被分为两个亚组：那些有和那些没有额叶功能障碍。平均4年后，进行第二次神经心理学检查，以评估精神状态的任何最终变化。结果表明，额叶功能障碍可能会观察到几年前出现的广泛性智力障碍，并可能被认为是帕金森病痴呆症的发展的预测因素之一。在运动能力检查中仔细考虑这些缺陷可能对帕金森病患者的临床治疗有价值。
The purpose of this longitudinal study was to investigate if the presence of frontal motor deficits in parkinsonians without signs of global intellectual impairment may have a predictive value for the development of a progressive dementing process during the course of the illness. An examination of the higher level of motor organization, using skills thought to depend upon the integrity of the frontal regions, was performed by 30 parkinsonian patients who did not present any signs of general intellectual impairment. According to their performance, as compared with controls, they were divided into two subgroups: those with and those without frontal dysfunctions. After a mean period of 4 years, a second neuropsychological examination was carried out to assess any eventual change of mental status. The results suggest that frontal dysfunctions may be observed several years before the appearance of generalized intellectual impairment and may be considered one of the predictive factors for development of dementia in Parkinson's disease. Careful consideration of these defects during examination of motor abilities may be of value in the clinical management of parkinsonian patients.