Subversion of innate host antiviral strategies by the hepatitis C virus
Subversion of innate host antiviral strategies by the hepatitis C virus
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DOI：
10.1016/j.abb.2007.03.033
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发表时间：
2007-06-15
影响因子：
3.9
通讯作者：
Haeussinger, Dieter
中科院分区：
文献类型：
--
作者：
Bode, Johannes G.;Brenndoerfer, Erwin D.;Haeussinger, Dieter
自1989年发现以来，丙型肝炎病毒（HCV）已被认为是慢性肝炎、终末期肝硬化和肝细胞癌的主要原因，影响全球超过2.1亿人。事实上，80%的新感染患者不能控制感染，明显的疾病和免疫反应的缓慢发展，以及目前的IFN/利巴韦林联合治疗的不满意的结果表明，丙型肝炎病毒发展强大的策略，以逃避和拮抗宿主的免疫反应，并抵制干扰素的抗病毒作用。在过去的10年中，已经发现了几种病毒策略，用于控制和逃避由病原体相关的分子模式识别受体RIG 1和TLR 3引发的细胞抗病毒宿主应答，并由I型干扰素的释放和随后的干扰素刺激基因的诱导介导。这篇综述强调了最近的结果，提供了一个想法，丙型肝炎病毒如何干扰不同的步骤，最初的抗病毒宿主反应，并建立持续感染。(C)2007年由Elsevier Inc.出版
Since its discovery in 1989, Hepatitis C Virus (HCV) has been recognized as a major cause of chronic hepatitis, end-stage cirrhosis and hepatocellular carcinoma affecting world wide more than 210 million people. The fact that 80% of newly infected patients fail to control infection, the slow development of overt disease and immune-response as well as the unsatisfying results of current IFN/ribavirin combination therapy suggests that the hepatitis C virus developed powerful strategies to evade and to antagonize the immune response of the host and to resist the antiviral actions of interferons. During the last 10 years several viral strategies have been uncovered for control and evasion from cellular antiviral host response initiated by the pathogen-associated molecular pattern recognizing receptors RIGI and TLR3 and mediated by the release of type I interferon and subsequent induction of interferon stimulated genes. This review highlights recent results providing an idea of how the hepatitis C virus interferes with the different steps of initial antiviral host-response and establishes persistent infection. (C) 2007 Published by Elsevier Inc.