First particle measurements with an integrated Coulter counter based on 2-dimensional aperture control
First particle measurements with an integrated Coulter counter based on 2-dimensional aperture control
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首次使用基于二维孔径控制的集成库尔特计数器进行粒子测量
DOI：
10.1109/sensor.2003.1215311
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Vellekoop
中科院分区：
文献类型：
--
作者：
J. H. Nieuwenhuis;F. Kohl;J. Bastemeijer;M. Vellekoop
本文介绍了一种带液体孔的集成库尔特计数器装置的首次测量结果。部分包围样品液体的非导电套液定义了库尔特孔。孔的尺寸可以通过改变样品液体和鞘液体的流速来动态调整。这种方法的一个优点是它防止了通道阻塞，因为通道的物理尺寸可以比库尔特孔径大得多。测量结果表明，在物理尺寸较大的通道中可以获得较高的灵敏度。
In this paper we present first-time measurement results for an integrated Coulter counter device with a liquid aperture. A non-conductive sheath liquid that partially surrounds the sample liquid defines the Coulter aperture. The dimensions of the aperture can be dynamically adapted by changing the flow-rates of the sample liquid and the sheath liquid. An advantage of this approach is that it prevents channel blocking, since the channel's physical dimensions can be much larger than the Coulter aperture. The measurement results show that a high sensitivity can be obtained in a channel with relatively large physical dimensions.