The effect of noise exposure during the developmental period on the function of the auditory system
The effect of noise exposure during the developmental period on the function of the auditory system
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DOI：
10.1016/j.heares.2016.03.008
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发表时间：
2017-09-01
期刊：
影响因子：
2.8
通讯作者：
Syka, Josef
中科院分区：
文献类型：
--
作者：
Bures, Zbynek;Popelar, Jiri;Syka, Josef
近年来，越来越多的证据表明，听觉系统的发育和成熟在很大程度上取决于向发育中心提供输入的传入活动。在这种活动在早期个体发育期间改变的情况下，例如，在不自然的声学环境或声学创伤中，听觉系统的结构和功能可能受到严重影响。病理改变可能存在于内毛细胞的带状突触群中，神经元回路的结构和功能中，或听觉驱动的行为和心理物理表现中。发育障碍的三个特征是至关重要的：第一，它们通常持续到成年，永久地影响受试者的生活质量;第二，它们的表现与成年期噪声创伤引起的障碍不同，有时甚至是矛盾的;第三，它们可能是“隐藏的”，难以通过临床实践中使用的标准听力测定程序进行诊断。本文综述了早期干预对听觉系统的影响，特别是个体发育过程中的声音暴露。我们总结了最近的形态，电生理和行为实验的结果，讨论了假定的机制和假设，并得出可能的后果，人类新生儿医学和噪声健康。(C)2016爱思唯尔B. V.保留所有权利。
Recently, there has been growing evidence that development and maturation of the auditory system depends substantially on the afferent activity supplying inputs to the developing centers. In cases when this activity is altered during early ontogeny as a consequence of, e.g., an unnatural acoustic environment or acoustic trauma, the structure and function of the auditory system may be severely affected. Pathological alterations may be found in populations of ribbon synapses of the inner hair cells, in the structure and function of neuronal circuits, or in auditory driven behavioral and psychophysical performance. Three characteristics of the developmental impairment are of key importance: first, they often persist to adulthood, permanently influencing the quality of life of the subject; second, their manifestations are different and sometimes even contradictory to the impairments induced by noise trauma in adulthood; third, they may be 'hidden' and difficult to diagnose by standard audiometric procedures used in clinical practice. This paper reviews the effects of early interventions to the auditory system, in particular, of sound exposure during ontogeny. We summarize the results of recent morphological, electrophysiological, and behavioral experiments, discuss the putative mechanisms and hypotheses, and draw possible consequences for human neonatal medicine and noise health. (C) 2016 Elsevier B.V. All rights reserved.