EVIDENCE FOR ACCELERATED SKIN WRINKLING AMONG DEVELOPMENTALLY DELAYED INDIVIDUALS WITH DOWNS-SYNDROME
EVIDENCE FOR ACCELERATED SKIN WRINKLING AMONG DEVELOPMENTALLY DELAYED INDIVIDUALS WITH DOWNS-SYNDROME
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DOI：
10.1016/0047-6374(93)90049-w
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发表时间：
1993-08-15
影响因子：
5.3
通讯作者：
PIACQUADIO, DJ
中科院分区：
文献类型：
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作者：
BRUGGE, KL;GROVE, GL;PIACQUADIO, DJ
唐氏综合征(DS)是一种与智力低下有关的遗传性疾病，据报道，这是一种加速衰老的状况。然而，很少有研究考察DS的年龄相关性变化，而且这些研究没有包括对照组。在本研究中，15名DS患者、14名发育迟滞(DD)对照(DD对照)和16名年龄在22~51岁、年龄相近的健康对照获得了一种无创、无痛且容易获得的反映皮肤随年龄变化的局部变化(皮肤皱纹)的测量方法。根据之前的研究结果，健康对照组没有显示出皮肤测量与年龄的相关性，这是根据之前的研究结果对这些受试者的年龄范围所预测的。然而，DS组在相对不曝晒和曝晒的皮肤部位的所有皮肤测量结果与年龄有显著的相关性。DD对照组与几个但不是所有皮肤部位的年龄也显示出显著的相关性，相关系数有小于DS的趋势；至少，与健康对照组相比，DS的几个皮肤指标显示出更大的数值，提示皮肤皱纹加速。这些结果提供了皮肤加速老化的证据，与没有遗传疾病和精神发育迟滞的健康人相比，DS患者和可能的(DD)患者的皮肤皱纹可能受到阳光照射的更大影响。
Down's Syndrome (DS) is a genetic disorder involving mental retardation which is reported to be a condition of accelerated aging. However, few studies exist which examine age-dependent changes in DS and these studies fail to include a control group. In the present study a non-invasive, painless, and easily obtainable measure reflecting age-dependent topographical changes of the skin (skin wrinkling) was obtained in 15 DS subjects, 14 developmentally disabled (DD) (mentally retarded) controls (DD controls) and 16 healthy controls of similar ages ranging from 22 to 51 years. The healthy control group failed to show correlations of skin measures with age, as predicted for the age-range of these subjects, based on results of previous studies. However, the DS group showed significant correlations of all skin measures from relatively non-sunexposed and sunexposed skin sites, with age. The DD control also showed significant correlations with age of several but not all skin sites and the correlation coefficients tended to be less than that of the DS; at least, when contrasted with the healthy controls the DS showed greater values of several skin measures suggestive of accelerated skin wrinkling. These results provide evidence for accelerated aging of the skin, and possibly greater effects of sunexposure on skin wrinkling, in DS and possibly (DD) individuals in contrast to healthy individuals without a genetic disorder and without mental retardation.