An integrative model of internal axoneme mechanics and external fluid dynamics in ciliary beating
An integrative model of internal axoneme mechanics and external fluid dynamics in ciliary beating
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DOI：
10.1006/jtbi.2000.2182
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发表时间：
2000-12-07
影响因子：
2
通讯作者：
Fauci, LJ
中科院分区：
文献类型：
--
作者：
Dillon, RH;Fauci, LJ
我们提出了一个单独纤毛的流体力学模型，它包含了动力蛋白臂的离散表示，轴突的被动弹性结构包括微管和连接蛋白链接。该模型基于浸入边界法（Peskin, 1977），将分子马达通过被动弹性结构产生的内力与由Navier-Stokes方程支配的外部流体力学耦合在一起。详细的几何信息是可用的，如微管之间的间距和剪切，单个微管的局部曲率和连接蛋白链接的拉伸。此外，电机的显式表示使我们能够灵活地纳入各种激活理论。在本文中，我们选择一个简单的激活理论，因此纤毛跳动不存在，但它是耦合流体-轴突系统的相互作用组分的一个紧急性质。本文给出了几种不同黏度的滑动崩解和纤毛跳动的计算机模拟的数值结果。(C) 2000年学术出版社。
We present a fluid-mechanical model of an individual cilium which incorporates discrete representations of the dynein arms, the passive elastic structure of the axoneme including the microtubules and nexin links. This model, based upon the immersed boundary method (Peskin, 1977), couples the internal force generation of the molecular motors through the passive elastic structure with the external fluid mechanics governed by the Navier-Stokes equations. Detailed geometric information is available, such as the spacing and shear between the microtubules, the local curvature of individual microtubules and the stretching of the nexin links. In addition, the explicit representation of the dynein motors allows us the flexibility to incorporate a variety of activation theories. In this article, we choose a simple activation theory so that the ciliary beat is not present, but is an emergent property of the interacting components of the coupled fluid-axoneme system. We present numerical results from computer simulations of sliding disintegration and ciliary beating with several different viscosities. (C) 2000 Academic Press.