Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo
Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo
复制标题
长期摄入黑果枸杞花青素对体内机体健康和肠道菌群的影响
DOI：
10.1016/j.foodres.2019.108952
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发表时间：
2020-04-01
影响因子：
8.1
通讯作者：
Cao, Youlong
中科院分区：
文献类型：
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作者：
Peng, Yujia;Yan, Yamei;Cao, Youlong
饮食，尤其是多酚类物质与健康之间的关系越来越受到人们的关注。多酚被肠道菌群降解为代谢物，作用于机体发挥多种生物活性，包括抗氧化应激、抗炎症、肠道屏障和调节肠道菌群等。长期给小鼠注射枸芪花青素（ACN）后，小鼠肝脏抗氧化能力（T-AOC、T-SOD、CAT、GSH和GSH- px升高，AST、ALT、ALP和MDA降低）、结肠抗炎能力（iNos、Cox-2、tnf - α、α -6、Il-1 β和ifn - γ mRNA表达显著降低）、肠道屏障能力（Zo-1、Occludin、Claudin-1和Mud mRNA表达显著升高）和肠道微生物群(Barnesiella；ACN组的Alistipes、Eisenbergiella、Coprobacter和Odorthacter均有增殖。同时，盲肠内容物和粪便中短链脂肪酸含量增加。综上所述，长期摄入ACN可促进机体健康，这些结果对ACN作为功能性食品原料的发展具有重要意义。
The relationship between diet, especially polyphenols, and health has been receiving increasing attention. Polyphenols were degraded by gut microbiota into metabolites and acted on the body to exert many bioactivities from several targets such as antioxidative stress, anti-inflammation, intestinal barrier and gut microbiota modulation. After long-term treatment of mice with anthocyanins from Lycium ruthenicum Murray (ACN), antioxidant status in liver (T-AOC, T-SOD, CAT, GSH and GSH-Px were increased and AST, ALT, ALP and MDA were decreased), anti-inflammatory status in colon (the expression of mRNA of iNos, Cox-2, Tnf-alpha, eta-6, Il-1 beta and Ifn-gamma were significantly reduced), intestinal barrier (the expression of mRNA of Zo-1 , Occludin, Claudin-1 and Mud were significantly increased) and gut microbiota (Barnesiella, Alistipes, Eisenbergiella, Coprobacter and Odorthacter were proliferated) were all regulated in ACN group. Meanwhile, the content of short-chain fatty acids in cecal contents and feces were increased. Taken together, long-term intake of ACN could promote organism healthy and these results have important implications for the development of ACN as a functional food ingredient.