Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer
Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer
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DOI：
10.1016/j.biomaterials.2004.07.014
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发表时间：
2005-05-01
期刊：
影响因子：
14
通讯作者：
Shinjo, T
中科院分区：
文献类型：
--
作者：
Kawashita, M;Tanaka, M;Shinjo, T
直径为20-30 μ m的亚铁磁性微球可用作热种子，用于在癌症中诱导热疗，特别是对于位于体内深处的肿瘤。当微球通过血管植入时，微球被截留在肿瘤的毛细血管床中，并且当置于交变磁场下时，微球通过其磁滞损失局部加热癌症。在本研究中，磁铁矿（Fe 3 O 4）微球的直径为20-30微米的制备尝试通过在高频感应热等离子体中熔融粉末，并从水溶液中沉淀。用高频感应热等离子体熔融法制备的微球由大量的Fe_3 O_4和少量的浮氏体（FeO）组成，在5.1 × 10 ~（3）Pa、600 ℃下热处理1h后，微球完全由1 μ m大小的Fe_3 O_4组成。热处理后的微球的饱和磁化强度和矫顽力分别为92 emu g I和50 Oe。在300 Oe和100 kHz下，热处理微球的热产生估计为10 Wg（-1）。通过从水溶液中沉淀制备的微球由β-FeOOH组成，并且随后在70%CO2 + 30%H-2气氛中在400 ℃下热处理1小时的微球由尺寸为50 nm的Fe 3 O 4晶体组成。热处理后的微球的饱和磁化强度和矫顽力分别为53 emu g（-1）和156 Oe。在300 Oe和100 kHz下，热处理微球的热生成估计为41 W g（-1）。后者的微球被认为是有前途的热种子的热治疗癌症。(C)2004爱思唯尔有限公司保留所有权利。
Ferrimagnetic microspheres 20-30 mum in diameter are useful as thermoseeds for inducing hyperthermia in cancers, especially for tumors located deep inside the body. The microspheres are entrapped in the capillary bed of the tumors when they are implanted through blood vessels and heat cancers locally by their hysteresis loss when placed under an alternating magnetic field. In the present study, preparation of magnetite (Fe3O4) microspheres 20-30 mum in diameter was attempted by melting powders in high-frequency induction thermal plasma, and by precipitation from aqueous solution. The microspheres prepared by melting powders in high frequency induction thermal plasma were composed of a large amount of Fe3O4 and a small amount of wustite (FeO), and those subsequently heat treated at 600 degreesC for 1 h under 5.1 X 10(3) Pa were fully composed of Fe3O4 I gm in size. The saturation magnetization and coercive force of the heat-treated microspheres were 92 emu g I and 50 Oe, respectively. The heat generation of the heat-treated microspheres was estimated to be 10Wg(-1), under 300 Oe and 100 kHz. The microspheres prepared by precipitation from aqueous solution consisted of beta-FeOOH, and those subsequently heat treated at 400 degreesC for 1 h in a 70% CO2 + 30% H-2 atmosphere consisted of Fe3O4 crystals 50 nm in size. The saturation magnetization and coercive force of the heat-treated microspheres were 53 emu g(-1) and 156 Oe, respectively. The heat generation of the heat-treated microspheres was estimated to be 41 W g(-1), under 300 Oe and 100 kHz. The latter microspheres are believed to be promising thermoseeds for hyperthermic treatment of cancer. (C) 2004 Elsevier Ltd. All rights reserved.