C-reactive protein and immunoglobulin-E response to coronary artery stenting in patients with stable angina
C-reactive protein and immunoglobulin-E response to coronary artery stenting in patients with stable angina
复制标题
DOI：
10.1536/jhj.44.593
复制
发表时间：
2003-09-01
期刊：
影响因子：
--
通讯作者：
Ozbay, G
中科院分区：
文献类型：
--
作者：
Erdogan, O;Altun, A;Ozbay, G
近年来的研究表明，炎症机制在动脉粥样硬化、新生内膜增生和冠状动脉再狭窄的发病机制中起着重要作用。为进一步研究支架植入术、再狭窄和炎症反应提供基线数据，我们前瞻性地进行了一项临床研究，以研究接受择期冠状动脉支架植入术的稳定患者中免疫球蛋白-E（IgE）和C-反应蛋白（CRP）血浆水平的时间相关反应，这是两种不同的炎症标志物，由不同的细胞因子介导。本研究纳入了13例接受冠状动脉支架植入术的连续稳定患者。在支架植入前和支架植入后连续4天以及第1个月和第3个月末测定I-E和CRP水平。这两种标志物的水平在术后逐渐升高，而IgE（初始278 335 IU/mL vs峰值350 489 IU/mL，P = 0.01）和CRP（初始0.5 +/- 0 mg/dL vs峰值2.7 +/- 3 mg/dL，P = 0.002）分别在第2天和第3天达到峰值。在支架植入后第一个月甚至第三个月结束时，高水平逐渐恢复到基线值，这意味着急性炎症反应。支架植入似乎不会引起任何持续和持续的炎症反应，在长期。
Recent reports indicate that inflammatory mechanisms play a crucial role in the patho-genesis of atherosclerosis and neointimal proliferation as well as coronary restenosis. To provide baseline data for further Studies regarding stenting, restenosis and inflammatory response, we prospectively conducted a clinical study to investigate the time related response of plasma levels of immunoglobulin-E (IgE) and C-reactive protein (CRP) which are two different inflammatory markers mediated by different cytokines in stable patients who underwent elective coronary artery stenting. Thirteen consecutive stable patients who underwent coronary artery stenting were included in the Study. Levels of I-E and CRP were determined pre- and poststent implantation on four consecutive days and at the end of the first as well as third month. Levels of these two markers were gradually elevated on postprocedure days while reaching peak values oil the second and third days for IgE (initial 278 335 IU/mL vs peak 350 489 IU/mL, P = 0.01) and CRP (initial 0.5 +/- 0 mg/dL vs peak 2.7 +/- 3 mg/dL, P = 0.002), respectively. High levels gradually returned to baseline values determined at the end of the first and even third months after stent implantation implying an acute inflammatory reaction. Stent implantation seems not to cause any persistent and ongoing inflammatory response in the long term.