Human lymphocyte and lymphoma homing receptors.
Human lymphocyte and lymphoma homing receptors.
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人类淋巴细胞和淋巴瘤归巢受体。
DOI：
10.1146/annurev.me.38.020187.002343
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发表时间：
1987
影响因子：
10.5
通讯作者：
Butcher,EC
中科院分区：
文献类型：
--
作者：
Jalkanen,S;Wu,N;Bargatze,RF;Butcher,EC
正常和恶性淋巴细胞的迁移在一定程度上是由淋巴细胞对血液中淋巴细胞出口部位的高内皮微静脉(HEV)的选择性识别控制的。循环淋巴细胞似乎利用结构相关但功能不同的90-kD受体，以器官特异性的方式与周围淋巴结、粘膜相关淋巴组织(Peyer氏结、阑尾)和炎症关节组织(滑膜)中的HEV相互作用。这些淋巴细胞“归巢受体”组成了一个糖蛋白内皮细胞识别元件家族，调节循环中的正常淋巴细胞和肿瘤淋巴细胞外溢到体内不同器官，从而在决定局部免疫反应的特征和淋巴肿瘤的扩散模式中发挥重要作用。
The migration of normal and malignant lymphocytes is controlled in part by selective lymphocyte recognition of high endothelial venules (HEV) at sites of lymphocyte exit from the blood. Recirculating lymphocytes appear to utilize structurally related, yet functionally distinct, 90-kD receptors to interact in an organ-specific manner with HEV in peripheral lymph nodes, in mucosa-associated lymphoid tissues (Peyer's patches, appendix), and in inflamed joint tissue (synovium). These lymphocyte "homing receptors" constitute a family of glycoprotein endothelial cell recognition elements that regulate the extravasation of circulating normal and neoplastic lymphocytes into different organs of the body, and thus play an important role in determining the characteristics of local immune responses and the patterns of dissemination of lymphoid neoplasms.
人类淋巴细胞归巢特性的体外分析：高内皮小静脉功能受体的发育调节。
影响因子：
20.3
作者：
Jalkanen,ST;Butcher,EC
通讯作者：
Butcher,EC