General anesthetic effects on protein kinase C
General anesthetic effects on protein kinase C
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DOI：
10.1016/s0378-4274(98)00170-2
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发表时间：
1998-11-23
影响因子：
3.5
通讯作者：
Hemmings, HC
中科院分区：
文献类型：
--
作者：
Hemmings, HC
(1)蛋白激酶C是一个磷脂依赖性蛋白激酶家族，参与多种细胞功能的调节。(2)有证据表明，某些全身麻醉药可以刺激蛋白激酶C的活性，通过与酶的调节结构域相互作用，可能与甘油二酯结合位点。麻醉剂也增强酶的激活依赖性下调。(3)PKC在介导和/或调节全身麻醉药的细胞效应中的作用是麻醉作用的潜在分子靶点。(C)1998由Elsevier Science爱尔兰有限公司出版。保留所有权利。
(1) Protein kinase C is a family of phospholipid-dependent protein kinases which are involved in the regulation of diverse cellular functions. (2) Evidence is emerging that certain general anesthetics can stimulate the activity of protein kinase C by interacting with the regulatory domain of the enzyme, possibly with the diacylglycerol binding sites. Anesthetics also potentiate activation-dependent down-regulation of the enzyme. (3) A role for PKC in the mediation and/or modulation of the cellular effects of general anesthetics is a potential molecular target for anesthetic action. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.